Browse Items · Pediatric Palliative Care Library

Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds

Endogenous opioids released from leukocytes extravasating into injured tissue can interact with peripheral opioid receptors to inhibit nociception. Animal studies have shown that the homing of opioid-producing leukocytes to the injured site is…

Tags: 2007, Adjuvants, Aged, Analgesia, Analgesics, Anesthesia, Anesthesia/immunology/pharmacology, Anesthetics, Backlog, beta-Endorphin/drug effects/immunology/metabolism, Biomarkers of Pain, Brain, Behavior, And Immunity, Bupivacaine/immunology/therapeutic use, Cell Movement/drug effects/immunology, Enkephalin, Epidural, Female, Fentanyl/immunology/therapeutic use, Heurich M, Humans, Journal Article, Kopf A, Lenzner M, Leukocytes/drug effects/immunology/metabolism, Local/immunology/therapeutic use, Longitudinal Studies, Male, Methionine/drug effects/immunology/metabolism, Middle Aged, Morciniec P, Mousa SA, Nociceptors/drug effects/immunology, Opioid/immunology/therapeutic use, Pain, Patient-Controlled, Pirinitramide/therapeutic use, Postganglionic/drug effects/immunology, Postoperative/immunology/prevention & control, Stein C, Subcutaneous Tissue/immunology, Sympathetic Fibers, Welte M, Wound Healing/drug effects/immunology

Inpatient-based intensive interdisciplinary pain treatment for highly impaired children with severe chronic pain: randomized controlled trial of efficacy and economic effects

Pediatric chronic pain, which can result in deleterious effects for the child, bears the risk of aggravation into adulthood. Intensive interdisciplinary pain treatment (IIPT) might be an effective treatment, given the advantage of consulting with…

Interdisciplinary management of adolescent chronic pain: developing the role of physiotherapy

Children and adolescents report chronic pain, and a significant minority develop pain associated distress and disability. Unidisciplinary and uni-modal treatments are rarely successful, but recent developments in interdisciplinary programmes of…

Tags: 2004, Adolescent, Backlog, Eccleston C, Eccleston Z, Journal Article, Pain, Physical therapy techniques, Physiotherapy

Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy

Background X-linked adrenoleukodystrophy (X-ALD) is a genetic peroxisomal disorder associated with tissue accumulation of very long chain fatty acids (VLCFAs). In approximately one third of affected males, this causes progressive and irreversible…

Tags: 1134-47-0 (baclofen), 1309378-01-5 (botulinum toxin A), 1638949-86-6 (botulinum toxin A), 1800016-51-6 (botulinum toxin A), 2018, 93384-43-1 (botulinum toxin A), Addison disease, adrenoleukodystrophy/dt [Drug Therapy], adrenoleukodystrophy/su [Surgery], Article, baclofen, Baclofen/dt [drug Therapy], baclofen/po [Oral Drug Administration], baclofen/tl [Intrathecal Drug Administration], balance disorder, behavior change, bladder dysfunction, botulinum toxin A, Case Report, Child, Clinical Article, clinical examination, clonus, diplopia, drug dose increase, Dystonia, Ehrstedt C, European Journal of Paediatric Neurology, Fatigue, hearing disorder, Hjartarson H T, Human, hyperpigmentation, intrathecal baclofen, intrathecal pump, Leukodystrophy, limited mobility, Male, Pain, pharmacologic interventions, Priority Journal, Quality Of Life, Range of Motion, School Child, Spasticity, strabismus, Tedroff K, tone and motor problems, urinary catheter, visual disorder, X chromosome linked disorder/dt [Drug Therapy], X chromosome linked disorder/su [Surgery], X-linked adrenoleukodystrophy

Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma

A 2.8-year-old female patient (11.6 kg) was admitted to the hospital for uncontrolled pain and swelling in the left leg relating to a metastatic neuroblastoma. Initially, her pain was managed with oral morphine 2 mg (approx. 0.2 mg/kg) every 4 hours.…

Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature

OBJECTIVE: Chronic cancer pain is often refractory and difficult to treat. Ketamine is a medication with evidence of efficacy in the treatment of chronic pain. DESIGN: This article presents a synthesis of the data on ketamine for refractory cancer…

Tags: 2013, Adult, Analgesics, Backlog, Bredlau AL, Child, Clinical Trials as Topic, Dworkin RH, Humans, Intractable, Journal Article, Ketamine, Korones DN, Neoplasms, Pain, Pain Management, Pain Medicine (malden, Mass.), Thakur R

Local analgesic effect of endogenous opioid peptides

Opioids produce analgesia by interacting with local opioid receptors in peripheral inflamed tissue. This study investigated whether endogenous ligands of these receptors are present in synovia and whether such opioid peptides can inhibit pain by…

Massage therapy for symptom reduction and improved quality of life in children with cancer in palliative care: A pilot study

Background: For children with cancer in palliative care, pain and worry are common and frequently under-managed, which negatively impacts quality of life (QOL). Massage therapy (MT) can lead to reduced pain in children with chronic illnesses.…

Massive opioid requirements in children with disseminated central nervous system disease

Massive opioid resistance in an infant with a localized metastasis to the midbrain periaqueductal gray

We report the case of a 4-month-old infant with terminal malignancy who had systemic metastases and a localized metastasis to the dorsal midbrain periaqueductal gray (PAG). Extraordinary doses of opioids (dose equivalent of 2680 mg morphine…

Medical marijuana use for pediatric oncology patients: single institution experience

Medical marijuana (MM) is widespread in many medical fields, including oncology, with limited use in pediatric oncology where research is scarce and often shows conflicting results. This research focuses on alleviating side effects of anticancer…

Medication utilization for symptom management by pediatric inpatients with cancer at end-of-life

Background: Despite advances in pediatric oncology care, most children that die each year from cancer report significant suffering at end-of-life. Commonly reported symptoms include pain, anxiety, and nausea. More than half of pediatric cancer…

Meditation experience predicts less negative appraisal of pain: electrophysiological evidence for the involvement of anticipatory neural responses

The aim of mindfulness meditation is to develop present-focused, non-judgmental, attention. Therefore, experience in meditation should be associated with less anticipation and negative appraisal of pain. In this study we compared a group of…

Methadone as treatment for iatrogenic narcotic dependency in pediatric intensive care unit patients

Methadone response in advanced cancer patients with pain followed at home

Concerns about the safety of therapy with methadone, which may arise because of its pharmacokinetic characteristics and inappropriate dosing, may deter clinicians from using this drug, especially in elderly patients. Experience is accumulating that…

Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

We have previously shown that beta-endorphin (END) is contained and released from memory-type T-cells within inflamed tissue and that it is capable to control pain (J Clin Invest 100(1) (1997) 142). Methionine-enkephalin (MET) and Dynorphin-A (DYN)…

Mobile Health-Collected Biophysical Markers in Children with Serious Illness-Related Pain

Context: There is an ongoing established need to develop engaging pain assessment strategies to provide more effective individualized care to pediatric patients with serious illnesses. This study explores the acceptability of wireless devices as one…

Tags: 2020, Ajayi TA, Cancer, February 2021 List, Journal of Palliative Medicine, mobile health, Pain, Pediatrics, Salongo L, sickle cell disease, Steinhubl S, Wineinger N, Zang Y

Morphine kinetics in children

The kinetics of morphine in the plasma of children (0 to 15 yr) can in most cases be adequately described by a triexponential function. When the dosage in children receiving morphine as premedication before surgery is based on kilograms of body…

N of 1 randomised controlled trials of oral ketamine in patients with chronic pain

Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with…

Tags: 1999, Administration, Analgesics/administration & dosage/therapeutic use, Backlog, Female, Gaines SP, Haines DR, Humans, Journal Article, Ketamine/administration & dosage/therapeutic use, Male, Oral, Pain, Pain/drug therapy/etiology/physiopathology, Placebos

Neonatal pain, parenting stress and interaction, in relation to cognitive and motor development at 8 and 18 months in preterm infants

Procedural pain in the neonatal intensive care unit triggers a cascade of physiological, behavioral and hormonal disruptions which may contribute to altered neurodevelopment in infants born very preterm, who undergo prolonged hospitalization at a…

Tags: 2009, Backlog, Cepeda IL, Grunau RE, Hubber-Richard P, Johannesen D, Journal Article, Keidar A, Mackay M, Pain, Petrie-Thomas J, Rogers M, Synnes AR, Whitfield MF

Neurontin: Clinical pharmacologic opinion of Dr. Thomas L. Perry

Based on a thorough and scientifically valid analysis of all relevant doubleblind randomized clinical trials (DBRCT), Neurontin is not an effective drug for thetreatment of neuropathic pain. My thorough review and meta-analysis of availablepublished…

Tags: 2008, Backlog, gabapentin [Substance Name], Hal's Folder, Journal Article, Pain, Perry TL

Non-communicating children's pain checklist: better pain assessment for severely disabled children

Advances in the treatment of pain for children with severe disabilities have lagged behind that for other children. This is due, in part, to a lack of valid assessment tools for their pain. The non-communicating children's pain checklists are…

Tags: 2003, Backlog, Breau LM, Child, Child Behavior Disorders, Child Development Deviations, Child Development Disorders, Child Psychology, Cognition Disorders, Developmental Disabilities, Expert Review Of Pharmacoeconomics And Outcomes Research, Journal Article, Mental Disorders, Mental Retardation, Minors, Pain, Pain Measurement

Nursing Care at End of Life in Pediatric Intensive Care Unit Patients Requiring Mechanical Ventilation

BACKGROUND: Parents' perceptions of critical care during the final days of their child's life shape their grief for decades. Little is known about nursing care needs of children actively dying in the pediatric intensive care unit (PICU). OBJECTIVES:…

Tags: 2022, Acute Disease, American Journal of Critical Care, April 2022 List, Asaro LA, Broden EG, Child, Curley MAQ, Death, Hinds PS, Humans, Intensive Care Units Pediatric, Neoplasms, Pain, Quinn R, Respiration Artificial, Werner-Lin A

Opioid dependence and addiction during opioid treatment of chronic pain

Throughout the long history of opioid drug use by humans, it has been known that opioids are powerful analgesics, but they can cause addiction. It has also been observed, and is now substantiated by multiple reports and studies, that during opioid…

Tags: 2007, Analgesics, Backlog, Ballantyne JC, Brain/drug effects/physiopathology, Chronic Disease, Humans, Journal Article, LaForge KS, Models, Neurological, Opioid-Related Disorders/etiology/physiopathology/prevention & control, Opioid/adverse effects/therapeutic use, Pain, Pain/drug therapy/physiopathology/psychology, Physician's Practice Patterns/trends

Opioid treatment for mixed pain in pediatric patients assisted by the Palliative Care team. Five years of experience

Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Depending on its pathophysiological mechanism, it may be classified into nociceptive, neuropathic, and mixed pain. If pain is…

Tags: 2018, Archivos Argentinos De Pediatria, Child, Gomez KV, Majdalani A, March 2018 List, Methadone, Morphine, opioid analgesics, Pain, Pigliapoco V, Santos Chocler G, Yazde Puleio ML

Opioids in chronic non-cancer pain: systematic review of efficacy and safety

Opioids are used increasingly for chronic non-cancer pain. Controversy exists about their effectiveness and safety with long-term use. We analysed available randomised, placebo-controlled trials of WHO step 3 opioids for efficacy and safety in…

Oral and dental considerations in pediatric cancers

Oral health care is an integral component of interprofessional collaborative care for children and adolescents diagnosed with cancer. The current review highlights the phases of cancer therapy when dental interventions and palliative care are…

Oral morphine versus transmucosal diamorphine for breakthrough pain in children: methods and outcomes: UK (DIPPER study) consensus

OBJECTIVES: No randomised controlled trials have been conducted for breakthrough pain in paediatric palliative care and there are currently no standardised outcome measures. The DIPPER study aims to establish the feasibility of conducting a…

Paediatric pain profile

The Paediatric Pain Profile is a tool that has been developed specially to help in assessing and monitoring pain in children with severe neurological impairments, especially those with impairments which lead them to be unable to communicate pain…

Tags: 2003, Backlog, Child, Health Care, Institute of Child Health, Journal Article, Pain, Pediatrics, Quality Assurance, Questionnaires, Royal College of Nursing Institute

Pain Assessment and Management in Pediatric Intensive Care Units Around the World, an International, Multicenter Study

The adequate assessment and management of pain remains a challenging task in the Pediatric Intensive Care Unit (PICU). Our goal is to describe how pain is assessed and managed in PICUs around the world and to examine how human and material resources…

Tags: 2021, Bustamante G, Cobo G, Frontiers in Pediatrics, Gavilanes AWD, Grunauer M, Icaza-Freire AP, January 2022 List, Mikesell C, Pain, Pediatric, pediatric critical care units, Pediatric Palliative Care, Roman AM, Sanchez S, under resourced settings, Wang NE

Pain in children and adolescents: a common experience

2000

Tags: 2000, Backlog, Bohnen AM, Hazebroek-Kampschreur AA, Hunfeld Joke AM, Journal Article, Pain, Passchier J, Perquin CW, van der Wouden JC, van Suijlekom-Smit Lisette WA

Pain in children with cerebral palsy: a review.

Children with cerebral palsy (CP) face many challenges including impaired motor control and coordination, functional impairment, sensory disturbances, and, sometimes, communication difficulties and cognitive deficits. Pain also may be a problem for…

Pain in children with cerebral palsy: common triggers and expressive behaviors.

To obtain parents' identification and description of the behaviors, health care procedures and daily living situations associated with pain in children with cerebral palsy (CP), surveys were sent to parents of children with CP recruited via a clinic…

Pain in cognitively impaired, non-communicating children

AIM To detail the everyday occurrence of pain in non-communicating children with cognitive impairment. METHODS Thirty four parents of cognitively impaired verbally non-communicating children completed pain diaries over a two week period. Each day,…

Tags: 2001, Archives of Disease in Childhood, Backlog, cognitive impairment, Journal Article, Lenton S, non-communicating, Pain, Stallard P, Velleman R, Williams L

Pain management at home in children with cancer: A daily diary study

Background With the transition of care of cancer patients from the hospital to the home setting, parents are largely responsible for children's pain management. Children's cancer pain is undermanaged, yet, there is little empirical data on the…

Tags: 2013, Backlog, Bruce C, daily diary, Fortier MA, Journal Article, Maurer EL, Pain, pain at home, Pain Management, Pediatric Blood & Cancer, Pediatric Oncology, Stevenson R, Wahi A

Pain management in children

Interest in the management and study of pain in children has increased in recent years. A range of techniques appropriate to children with different developmental levels is now available for the assessment of various aspects of childhood pain. A…

Tags: 1991, Anti-Inflammatory Agents, Backlog, British Medical Bulletin, Child, Goldman A, Humans, Infant, Journal Article, Lloyd-Thomas AR, Narcotics/therapeutic use, Neoplasms/complications, Newborn, Non-Steroidal/therapeutic use, Pain, Pain Measurement/methods, Pain/drug therapy/etiology, Postoperative/drug therapy, Preschool

Pain management: a quality improvement project

Pain management in the PACU is vital to patient care and favorable outcomes. Understanding all aspects of pain management is essential when caring for surgical patients. Most PACUs have quality improvement (QI) and/or risk management projects that…

Tags: 1997, Backlog, Dolezal D, Humans, Journal Article, Journal Of Perianesthesia Nursing, Pain, Postoperative/nursing/therapy, Program Evaluation, Quality of Health Care/organization & administration, RDF Project, Recovery Room/standards, Rittenmeyer H, Vogel E

Pain medication during terminal care of children with cancer

The purpose of this study was to evaluate the need for pain medication and the adequacy or inadequacy of the analgesia achieved, in children with cancer who died while in terminal care. Of the 100 pediatric patients with cancer treated at the…

Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial

INTRODUCTION: Pain negatively affects the health-related quality of life (HRQL) of adolescents with cancer. The Pain Squad+ smartphone-based application (app), has been developed to provide adolescents with real-time pain self-management support. The…

Palliative Care for Childhood Cancer

Cure rates for children with cancer are improving, but often at the cost of quality of life during treatment [...].

Browse Items (210 total)