Neurontin: Clinical pharmacologic opinion of Dr. Thomas L. Perry

Neurontin: Clinical pharmacologic opinion of Dr. Thomas L. Perry

Perry TL

2008

Pain; Hal's Folder; gabapentin [Substance Name]

Based on a thorough and scientifically valid analysis of all relevant doubleblind randomized clinical trials (DBRCT), Neurontin is not an effective drug for thetreatment of neuropathic pain. My thorough review and meta-analysis of availablepublished and unpublished evidence shows that Neurontin (gabapentin) has at besta clinically insignificant average effect on pain scores. The proportion of patientswho recognize “improvement” on a Patient Global Impression of Change scale atthe end of studies is roughly matched by the proportion of patients who experienceadverse events. In the real world, to which the concept of “effectiveness” applies,patients taking Neurontin (gabapentin) should be expected to accrue less benefit andmore harm. Thus, in my opinion, Neurontin (gabapentin) has not beendemonstrated to be an effective treatment for pain.

2008

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Journal Article

Backlog