Browse Items · Pediatric Palliative Care Library

Setting-up a Supportive and Palliative Care Service for Children with Life-threatening Illnesses in Maharashtra -- Children's Palliative Care Project in India

Objectives: To describe the key initiatives that were successful in planning and implementing hospital- and community-based Paediatric Palliative Care (PPC) services designed for a resource-limited setting in Maharashtra, India, in collaboration with…

Good-Parent Beliefs: Research, Concept, and Clinical Practice

Parents of ill children have willingly identified their personal beliefs about what they should do or focus on to fulfill their own internal definition of being a good parent for their child. This observation has led to the development of the…

Tags: 2020, 2022 Special Edition 1 - Parent Perspectives, Administration, Communication Skills, Feudtner C, Hinds PS, Hospice, interpersonal skills, October T, Palliative Medicine, Parent, Pediatrics, Practice Management, Weaver MS

"Good-Parent Beliefs": Research, Concept, and Clinical Practice

Parents of ill children have willingly identified their personal beliefs about what they should do or focus on to fulfill their own internal definition of being a good parent for their child. This observation has led to the development of the…

Tags: 2020, Administration, Communication Skills, Feudtner C, Hinds P S, Hospice, interpersonal skills, July 2020 List, October T, Palliative Medicine, Pediatrics, Practice Management, Weaver M S

Intranasal fentanyl for respiratory distress in children and adolescents

Respiratory distress is one of the most common and frightening symptoms of children with life-limiting conditions. Because treatment of the underlying cause is frequently impossible or insufficient, in many children, symptomatic treatment is…

Trends in the use of opioids at the end of life and the expected effects on hastening death

The aim of our study was to describe trends in opioid use and perceptions of having hastened the end of life of a patient. In 2005, a questionnaire was sent to 6860 physicians in The Netherlands who had attended a death. The response rate was 78%. In…

Opioid use in palliative care of children and young people with cancer

OBJECTIVE: Identify opioids prescribed, preferred routes, and doses among children with incurable cancer. STUDY DESIGN: Prospective survey with monthly questionnaires regarding patients 0 to 19 years old from oncology centers. Data were collected by…

A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma

OBJECTIVE: Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal…

Cost-effectiveness analysis of ziprasidone versus haloperidol in sequential intramuscular/oral treatment of exacerbation of schizophrenia: economic subanalysis of the ZIMO trial.

OBJECTIVE: This study aimed to assess the cost effectiveness of ziprasidone versus haloperidol in sequential intramuscular (IM)/oral treatment of patients with exacerbation of schizophrenia in Spain. METHODS: A cost-effectiveness analysis from the…

Transdermal fentanyl in the management of children with chronic severe pain: results from an international study

BACKGROUND: The current study was conducted to assess the safety and tolerability of a transdermal fentanyl delivery system for the relief of chronic pain in a pediatric population, and also to validate titration recommendations and conversion to…

Analgesic effects of topical methadone: a report of four cases

Topical morphine has been used on open wounds for pain management, but has a variable duration of action not suitable for palliative dressing changes. The objective of this study is to find an opioid and delivery method that would provide…

State of the science: procedural pain management in the neonate

Neonates in the neonatal intensive care unit experience painful procedures. Over the last 10 years, investigators have examined several pharmacologic and nonpharmacolgic treatment strategies to decrease or eliminate the pain associated with…

Tags: 2006, Administration, Artificial/adverse effects Sucking Behavior Sucrose/administration & dosage, Backlog, Central Venous/adverse effects Evidence-Based Medicine Glucose/administration & dosage Humans Infant Care Infant, D'Apolito KC, Human Neonatal Nursing/organization & administration Nurse's Role Nursing Assessment Nursing Research Pain/diagnosis/etiology/prevention & control Pain Measurement Phlebotomy/adverse effects Respiration, Intratracheal/adverse effects Milk, Journal Article, Journal of Perinatal & Neonatal Nursing, Neonatal/methods Intubation, Newborn Intensive Care, OralAnalgesia/methods/nursing Analgesics/therapeutic use Catheterization, PedPal Lit

Oral methadone for chronic noncancer pain: a systematic literature review of reasons for administration, prescription patterns, effectiveness, and side effects

OBJECTIVE: To assess the indications, prescription patterns, effectiveness, and side effects of oral methadone for the treatment of chronic noncancer pain. METHODS: We conducted searches of several electronic databases, textbooks and reference lists…

Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study

PURPOSE: The purpose of this study was to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Delta-9-THC) and cannabidiol (CBD). PATIENTS AND…

Utilizing an oral sucrose solution to minimize neonatal pain

ISSUES AND PURPOSE: To present an evidence-based practice protocol for oral sucrose administration to minimize neonatal procedural pain. CONCLUSION: Examination of published research may provide additional modalities to expand an established…

Changes in availability of paediatric medicines in Australia between 1998 and 2002

2005

Tags: 2005, Administration, and those both licensed for paediatric use and subsidized increased from 356 (23.1%) to 441 (23.2%). The number of medicines with formulations suitable for paediatric use increased from 861 (55.7%) to 967 (50.8%), Backlog, British Journal of Clinical Pharmacology, but not for children under the age of two years., Chui J, ei ght (9%) for 2-11 years and 12 (13%) for 12-18 years. An additional 14 orally available chemical entities previously only licensed for adults, Journal Article, licensed medicines available in Australia in the calendar years 1998 and 2002 were examined. RESULTS: The total number of medicines licensed in Australia increased from 1544 to 1903, Newborn Licensure, Oral Adolescent Age Factors Australia Chemistry, PedPal Lit, Pharmaceutical Child Child, Preschool Dosage Forms Drug Approval/statistics & numerical data Humans Infant Infant, Reith D, statistics & numerical data, the number of licensed paediatric items increased from 579 (37.5%) to 725 (38.1%), Tordoff J, trends Pediatrics, trends Pharmaceutical Preparations, were licensed for children by 2002. CONCLUSIONS: There have been some improvements in medicines licensing for older children

Bisphosphonate treatment of bone disease

In 1997 a review article on bisphosphonates in this journal identified 24 published articles relating to children at that time. Since then there has been a considerable increase in their use in clinical paediatric practice and research with there…

The decision to use topical anesthetic for intravenous insertion in the pediatric emergency department

OBJECTIVES: Topical anesthetic creams to reduce the pain of intravenous (IV) placement may be more effectively used in the emergency setting if they are applied by nurses in the triage area of the emergency department or soon after the patient is…

Beta-endorphin concentration after administration of sucrose in preterm infants

BACKGROUND: Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE: To…

Oral morphine and respiratory function amongst hospice inpatients with advanced cancer

BACKGROUND: Respiratory depression is the opioid adverse effect feared most by physicians. This may hinder adequate dosing in cancer pain. The study was conducted to examine the respiratory function of patients with advanced cancer receiving…

Clinical pharmacokinetics of morphine

Morphine, the most widely used mu-opioid analgesic for acute and chronic pain, is the standard against which new analgesics are measured. A thorough understanding of the pharmacokinetics of morphine is required in order to safely and effectively use…

Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma

A 2.8-year-old female patient (11.6 kg) was admitted to the hospital for uncontrolled pain and swelling in the left leg relating to a metastatic neuroblastoma. Initially, her pain was managed with oral morphine 2 mg (approx. 0.2 mg/kg) every 4 hours.…

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies

Three Cannabis Based Medicinal Extracts (CBMEs) for sublingual use became available in 2000. A total of 34 'N of 1' studies were undertaken using this novel therapy for patients with chronic, mainly neuropathic, pain and associated symptoms to…

Topical and peripherally acting analgesics

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially…

Tags: 2003, Administration, Afferent/drug effects/metabolism/physiology, Analgesics/administration & dosage/pharmacology/therapeutic use, Animals, Backlog, Humans, Journal Article, Neurons, Nociceptors/metabolism/physiology, Non-U.S. Gov't, Pain/drug therapy/metabolism/physiopathology, Peripheral Nervous System/drug effects, Pharmacological Reviews, Research Support, Sawynok J, Signal Transduction/drug effects/physiology, Topical

Oral pharmacotherapy of childhood movement disorders

Movement disorders, a common problem in children with neurologic impairment, are receiving increasing clinical attention. The differences in movement disorders between adults and children are striking; presentation is frequently insidious and may be…

Tags: 2003, Administration, Age of Onset, Ataxia/drug therapy, Backlog, Basal Ganglia/physiopathology, Child, Edgar TS, Humans, Hyperkinesis/drug therapy, Hypokinesia/drug therapy, Journal Article, Journal of Child Neurology, Movement Disorders/drug therapy/physiopathology, Muscle Hypotonia/drug therapy/physiopathology, Muscle Spasticity/drug therapy, Neuromuscular Agents/administration & dosage, Oral, Posture

Sublingual lorazepam at home for acute treatment of seizures

eizures are often initially treated at home. The standard treatment is rectal diazepam. Sublingual (SL) lorazepam is easy to administer but has not been well evaluated for efficacy in epilepsy. It has been reported to be effective for serial seizures…

Tags: 2003, Administration, Allen A, Archives of Disease in Childhood, Backlog, Benzodiazepinones, Bjelajac A, Chlorobenzenes, Convulsions, Epilepsy, home care services, Home Nursing, Journal Article, Lorazepam, Oral, Seizures, Sublingual, Wassmer E, Weiss S

Sublingual absorption of selected opioid analgesics

Ongoing interest in the improvement of pain management with opioid analgesics had led to the investigation of sublingual opioid absorption. The present report determined the percent absorption of selected opioid analgesics from the oral cavity of…

The use of oral methadone to control moderate and severe pain in children and young adults with malignancy

Twenty-two courses of oral methadone were given to control moderate or severe pain in 19 children with cancer. Of these, 21 courses gave adequate pain control for periods of 5 to 267 days (median 24 days). In 16 courses, methadone was continued until…

Tags: 1986, Administration, Adolescent, Backlog, Child, Journal Article, Methadone, Miser AW, Miser JS, Neoplasms, Oral, Pain, The Clinical Journal Of Pain

Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine

BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:1 between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose…

Methadone is safe for treating hospitalized patients with severe pain

PURPOSE: Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients. The infrequent use of methadone is probably due to its long plasma half-life that could lead to…

Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain

Direct conversion from oral morphine to transdermal fentanyl with a ratio of oral morphine/transdermal fentanyl (100:1 mg) daily was examined in patients with cancer pain. Patients with a 'stable and low level of cancer pain' receiving a constant…

Tags: 1996, Administration, Adult, Aged, Analgesics, Backlog, Cutaneous, Donner B, Female, Fentanyl, Humans, Journal Article, Male, Middle Aged, Morphine, Neoplasms, Opioid, Pain, Pain Measurement, Regression Analysis, Strumpf M, Tryba M, Zenz M

Transdermal fentanyl: clinical pharmacology

The transdermal therapeutic system (TTS) fentanyl has been designed for rate-controlled drug delivery. It provides a convenient regimen for the use of a drug previously limited by a short duration of action and a noninvasive parenteral route for a…

Tags: 1992, Administration, Backlog, Cutaneous, Fentanyl/administration & dosage/pharmacokinetics/pharmacology, Humans, Journal Article, Journal of Pain and Symptom Management, Lehmann KA, Zech D

Systemic lidocaine for neuropathic pain relief

The effectiveness of systemic lidocaine in relieving acute and chronic pain has been recognized for over 35 years. In particular, systemic lidocaine has been utilized both as a diagnostic and therapeutic tool for intractable neuropathic pain during…

Tags: 2000, Administration, Analgesics/administration & dosage/diagnostic use/therapeutic use, Animals, Backlog, Chen LL, Humans, Journal Article, Lidocaine/administration & dosage/diagnostic use/therapeutic use, Mao J, Mexiletine/therapeutic use, Neuralgia/drug therapy/metabolism, Oral, P.H.S., Pain, Research Support, Sodium Channel Blockers, U.S. Gov't

An update on the clinical use of methadone for cancer pain

Methadone is a synthetic opioid agonist considered a second choice drug in the management of cancer pain. Methadone has a number of unique characteristics including excellent oral and rectal absorption, no known active metabolites, high potency, low…

Tags: 1997, Administration, Analgesics, Backlog, Bruera E, Evaluation Studies, Humans, Journal Article, Methadone/administration & dosage/adverse effects/therapeutic use, Neoplasms/drug therapy, Non-U.S. Gov't, Opioid/administration & dosage/adverse effects/therapeutic use, Oral, Pain, Palliative Care/trends, Rectal, Research Support, Ripamonti C, Zecca E

N of 1 randomised controlled trials of oral ketamine in patients with chronic pain

Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with…

Tags: 1999, Administration, Analgesics/administration & dosage/therapeutic use, Backlog, Female, Gaines SP, Haines DR, Humans, Journal Article, Ketamine/administration & dosage/therapeutic use, Male, Oral, Pain, Pain/drug therapy/etiology/physiopathology, Placebos

Tags: 1996, Administration, Adolescence, Adult, Backlog, Child, Chronic Disease, Disabled Persons, Human, Infant, Jan JE, Journal Article, Journal Of Pineal Research, Melatonin/ae [Adverse Effects], Melatonin/tu [Therapeutic Use], O'Donnell ME, Oral, Preschool, Sleep Disorders/dt [Drug Therapy]

Browse Items (52 total)