The use of oral methadone to control moderate and severe pain in children and young adults with malignancy

The use of oral methadone to control moderate and severe pain in children and young adults with malignancy

Miser AW; Miser JS

The Clinical Journal Of Pain

1986

Child; Pain; Methadone; adolescent; Administration; Oral; Neoplasms

Twenty-two courses of oral methadone were given to control moderate or severe pain in 19 children with cancer. Of these, 21 courses gave adequate pain control for periods of 5 to 267 days (median 24 days). In 16 courses, methadone was continued until death or until the pain resolved; in five remaining courses, a change to parenteral narcotics was ultimately required. Toxicity was minimal. A safe starting dose of methadone appears to be 0.1 mg/kg given every 4 hours, or the equivalent total daily dose given less frequently, with escalation as required to achieve and maintain adequate pain control.

1986

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