Opioid switch to oral methadone in cancer pain

Title

Opioid switch to oral methadone in cancer pain

Creator

Mancini I; Lossignol DA; Body JJ

Publisher

Current Opinion In Oncology

Date

2000

Subject

Cross-Sectional Studies; Humans; Analgesics; Combined Modality Therapy; Administration; Oral; Pain/drug therapy/etiology; Dose-Response Relationship; Drug; Neoplasms/complications; Receptors; Opioid/administration & dosage/therapeutic use; Morphine/administration & dosage/therapeutic use; Methadone/administration & dosage/therapeutic use; N-Methyl-D-Aspartate/antagonists & inhibitors

Description

The occurrence of undesirable side effects due to opioids (delirium, confusion, myoclonus, nausea, emesis) is one of the major complications in the management of pain, especially in chronic cancer pain states. Methadone, as an alternative to morphine, has been proposed in the control of opioid-induced toxicity. Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors. Questions have arisen concerning its equianalgesic ratio since its rediscovery over the past few years and are certainly related to its receptor interactions. Aspects of its pharmacology, indications, and switching modalities are discussed here. Opioid rotation is a new tool in the management of cancer pain, deserving more attention.
2000

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

308-313

Issue

4

Volume

12

Citation

Mancini I; Lossignol DA; Body JJ, “Opioid switch to oral methadone in cancer pain,” Pediatric Palliative Care Library, accessed December 6, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12025.

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