Methadone is safe for treating hospitalized patients with severe pain

Title

Methadone is safe for treating hospitalized patients with severe pain

Creator

Shir Y; Rosen G; Zeldin A; Davidson EM

Identifier

Publisher

Canadian Journal Of Anaesthesia

Date

2001

Subject

Child; Female; Hospitalization; Humans; Male; Adult; Analgesics; Aged; Middle Aged; Analgesia; adolescent; Preschool; infant; Administration; Oral; retrospective studies; Pain/drug therapy; Pain Measurement/drug effects; Epidural; Methadone/administration & dosage/adverse effects/therapeutic use; Monitoring; Opioid/administration & dosage/adverse effects/therapeutic use; Physiologic

Description

PURPOSE: Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients. The infrequent use of methadone is probably due to its long plasma half-life that could lead to accumulation and toxicity. In the present study we report that clinically effective analgesic doses of methadone, given either epidurally or orally, can be used safely for prolonged treatment in hospitalized patients. Clinical features: Over a five-year period we administered methadone at Hadassah Hospital in Jerusalem to 3,954 in-patients with severe pain, 12% of whom were younger than 17 yr. Satisfactory pain relief was recorded in more than 85% of the patients. None of the patients treated with oral methadone developed serious side effects. Three patients, treated with epidural methadone (0.09%), developed a clinically significant respiratory depression. In all three cases, epidural pump failure or pump misprogramming resulted in methadone overdose. None of the children or adults treated with methadone developed addiction during hospitalization. CONCLUSION: Based on its analgesic properties and marked safety profile, we suggest that methadone could be added to the analgesic armamentarium of in-hospital health-care providers. Moreover, methadone could serve as the opioid of first choice in some in-patient populations.
2001

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

1109-1113

Issue

11

Volume

48

Citation

Shir Y; Rosen G; Zeldin A; Davidson EM, “Methadone is safe for treating hospitalized patients with severe pain,” Pediatric Palliative Care Library, accessed July 6, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12310.

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