Opioid dependence and addiction during opioid treatment of chronic pain

Title

Opioid dependence and addiction during opioid treatment of chronic pain

Creator

Ballantyne JC; LaForge KS

Publisher

Pain

Date

2007

Subject

Humans; Analgesics; Models; Chronic disease; Opioid/adverse effects/therapeutic use; Neurological; Physician's Practice Patterns/trends; Brain/drug effects/physiopathology; Opioid-Related Disorders/etiology/physiopathology/prevention & control; Pain/drug therapy/physiopathology/psychology

Description

Throughout the long history of opioid drug use by humans, it has been known that opioids are powerful analgesics, but they can cause addiction. It has also been observed, and is now substantiated by multiple reports and studies, that during opioid treatment of severe and short-term pain, addiction arises only rarely. However, when opioids are extended to patients with chronic pain, and therapeutic opioid use is not confined to patients with severe and short-lived pain, compulsive opioid seeking and addiction arising directly from opioid treatment of pain become more visible. Although the epidemiological evidence base currently available is rudimentary, it appears that problematic opioid use arises in some fraction of opioid-treated chronic pain patients, and that problematic behaviors and addiction are problems that need to be addressed. Since the potentially devastating effects of addiction can substantially offset the benefits of opioid pain relief, it seems timely to reexamine addiction mechanisms and their relevance to the practice of long-term opioid treatment for pain. This article reviews the neurobiological and genetic basis of addiction, its terminology and diagnosis, the evidence on addiction rates during opioid treatment of chronic pain and the implications of biological mechanisms in formulating rational opioid treatment regimes.
2007

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

235-255

Issue

3

Volume

129

Citation

Ballantyne JC; LaForge KS, “Opioid dependence and addiction during opioid treatment of chronic pain,” Pediatric Palliative Care Library, accessed July 24, 2021, https://pedpalascnetlibrary.omeka.net/items/show/14361.

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