Browse Items · Pediatric Palliative Care Library

Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis

We report on an 8 years and 3 months old boy with severe idiopathic juvenile osteoporosis (IJO). Clinical features included multiple fractures, especially of the vertebrae, and neurological symptoms. Biological studies showed non-parathyroid…

A literature review on off-label drug use in children

The aim was to compare results of studies performed in different settings worldwide and identify common therapeutic areas to allow for focused interventions, because off-label drug use can be a measure of the lack of knowledge concerning paediatric…

Osteoporosis at presentation of childhood ALL: management with pamidronate

Vertebral fractures at diagnosis of childhood acute lymphoblastic leukemia (ALL) are an uncommon but recognized problem. Clinical issues associated with pathological fractures in these children include pain control and the potential for further…

Children in reviews: methodological issues in child-relevant evidence syntheses

BACKGROUND: The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions…

Tags: 2005, Backlog, Bmc Pediatrics, Clodronate, Cramer K, Hartling L, Journal Article, Klassen TP, Moyer V, PedPal Lit, Swingler G, Wiebe N, Williams K

Bisphosphonates for the relief of pain secondary to bone metastases

BACKGROUND: Bisphosphonates form part of standard therapy for hypercalcemia and the prevention of skeletal events in some cancers. However, the role of bisphosphonates in pain relief for bony metastases remains uncertain. OBJECTIVES: To determine the…

Tags: 2002, Analgesics, Antineoplastic Agents/therapeutic use, Backlog, Bone Neoplasms/complications/drug therapy/secondary, Clodronate, Clodronic Acid/therapeutic use, Cochrane Database of Systematic Reviews, Diphosphonates/therapeutic use, Etidronic Acid/therapeutic use, Humans, Journal Article, Non-Narcotic/therapeutic use, Pain/drug Therapy, Randomized Controlled Trials, Wiffen PJ, Wong R

Osteopenia in children with acute lymphoblastic leukemia: a pilot study of amelioration with Pamidronate

Bisphosphonate mechanism of action

The nitrogen-containing bisphosphonates (N-BPs), alendronate and risedronate, are the only pharmacologic agents shown to prevent spine and nonvertebral fractures associated with postmenopausal and glucocorticoid-induced osteoporosis. At the tissue…

Tags: 2003, Apoptosis, Backlog, Bone Resorption/metabolism, Clodronate, Current Rheumatology Reports, Diphosphonates/chemistry/metabolism/pharmacology, Humans, Journal Article, Mevalonic Acid/antagonists & inhibitors, Osteoclasts/drug effects/metabolism/physiology, Osteoporosis/metabolism, Reszka AA, Rodan GA

Short-term safety assessment in the use of intravenous zoledronic acid in children

The clinical side effects of the potent new bisphosphonate zoledronic acid in children are unknown. In this study of 34 children with various bone disorders, the frequency of postinfusion flu-like illness, hypocalcemia, and hypophosphatemia was 85%,…

The use of subcutaneous pamidronate

2003

Tags: 2003, Anti-Inflammatory Agents/administration & dosage, Backlog, Clodronate, Diphosphonates/administration & dosage, Duncan AR, Humans, Hypercalcemia/drug therapy, Injections, Journal Article, Journal of Pain and Symptom Management, Subcutaneous

Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration

Bisphosphonates have become standard treatment in management of malignancy-induced hypercalcemia and malignant bone pain. One obstacle to the routine use of bisphosphonates in palliative patients is that oral bisphosphonates have low bioavailability…

New uses of bisphosphonates: osteogenesis imperfecta

Osteogenesis imperfecta is a heterogeneous group of inherited disorders chiefly affecting type I collagen, resulting in bone fragility responsible for a host of recurrent fractures. Limb and spine deformities, growth failure and restricted mobility…

Tags: 2002, Backlog, Bone Density/drug effects, Clodronate, Current Opinion in Pharmacology, Devogelaer JP, Diphosphonates/pharmacology/therapeutic use, Humans, Journal Article, Osteogenesis Imperfecta/classification/diagnosis/drug therapy

Use of bisphosphonate therapy for osteoporosis in childhood and adolescence

Congenital and acquired forms of osteoporosis in childhood and adolescence can result in morbidity from fracture and pain in childhood, and place an individual at significant risk for problems in adult life. A range of therapies exist for the…

Modern approach to children with osteogenesis imperfecta

Osteogenesis Imperfecta (OI) is characterized by bone fragility. At least seven discrete types have been described ranging from mild disease to a lethal form. In a large number of cases, mutations in one of the two genes encoding type I collagen have…

Uses of drugs not described in the package insert (off-label uses)

New regulatory initiatives have been designed to ensure that new drugs and biologicals include adequate pediatric labeling for the claimed indications at the time of, or soon after, approval. However, because such labeling may not immediately be…

Modern therapy for Paget's disease of bone: focus on bisphosphonates

There has been a dramatic change in the therapeutic approach to patients with Paget's disease of bone over the last 40 years. In the 1960s, only symptomatic therapy could be given, with control of pain the main objective. Analgesics and nonsteroidal…

Tags: 2002, Animals, Antimetabolites/administration & dosage/adverse effects/therapeutic use, Backlog, Clodronate, Devogelaer JP, Diphosphonates/administration & dosage/adverse effects/therapeutic use, Humans, Journal Article, Osteitis Deformans/drug therapy, Treatments In Endocrinology

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration…

Tags: 1987, Backlog, Child, Clodronate, Devogelaer JP, Diphosphonates/therapeutic use, Female, Follow-up Studies, Humans, Journal Article, Maldague B, Malghem J, Nagant de Deuxchaisnes C, Osteogenesis Imperfecta/drug therapy/radiography, Skeletal Radiology

Diphosphonates: history and mechanisms of action

The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium…

Diphosphonates in the treatment of myositis ossificans

Diphosphonate treatment of Paget's disease

Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in…

The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience

OBJECTIVE: To review the feasibility and effectiveness of n-of-1 randomized controlled trials (n-of-1 trials) in clinical practice. DESIGN: Individual trials were double-blind, randomized, multiple crossover trials. The impact of n-of-1 trials was…

A double-blind, crossover trial of intravenous clodronate in metastatic bone pain

After a baseline symptom and laboratory assessment, 24 patients with metastatic bone disease and pain were randomized to receive either a 4-hr intravenous infusion of 2-dichloromethylene bisphosphonate (Cl2MDP), 600 mg in 500 mL of normal saline, or…

Bisphosphonates: a review of their pharmacokinetic properties

Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and…

Tags: 1996, Animals, Backlog, Biological Availability, Blood Proteins/metabolism, Bone, Clodronate, Diphosphonates/pharmacokinetics/urine, Dose-Response Relationship, Drug, Humans, Intestinal Absorption/physiology, Journal Article, Lin JH, Protein Binding, Structure-Activity Relationship, Tissue Distribution/physiology

Expanding role of bisphosphonate therapy in children

1999

Tags: 1999, Backlog, Bone Diseases/drug therapy, Calcinosis/drug therapy, Child, Clodronate, Diphosphonates/pharmacokinetics/pharmacology/therapeutic use, Humans, Hypercalcemia/drug therapy, Journal Article, Shoemaker LR, The Journal Of Pediatrics

A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain

To evaluate the effectiveness of intravenous clodronate in ameliorating refractory bone pain in patients with metastatic bone disease, 60 patients with established osseous metastases and persistent bone pain were randomized to receive either…

Subcutaneous clodronate: a study evaluating efficacy in hypercalcemia of malignancy and local toxicity

The logistics of administering intravenous bisphosphonates may be problematic in the care of advanced cancer patients, especially in the home setting. Hypodermoclysis is a convenient method of administering fluid via subcutaneous infusion, presently…

Cyclic administration of pamidronate in children with severe osteogenesis imperfecta

BACKGROUND: Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of…

Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates

OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis. METHODS: Three children (ages 9 to 11 years) with osteoporosis pseudoglioma syndrome…

Bisphosphonates: from grandparents to grandchildren

Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. Bisphosphonates have been extensively used in the elderly with primary and secondary osteoporosis, Paget's disease, and…

Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care

This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to…

Bisphosphonates for treatment of childhood hypercalcemia

Most clinicians only have a limited experience in treating childhood hypercalcemia with bisphosphonates. We report our experience in the use of intravenous and oral bisphosphonates in a 5-year-old with hypercalcemia secondary to acute lymphocytic…

Bisphosphonates: mechanisms of action

1998

Tags: 1998, Animals, Backlog, Bone Development/drug effects, Bone Resorption/physiopathology, Clodronate, Diphosphonates/chemistry/metabolism/pharmacology, Endocrine Reviews, Fleisch H, Humans, Journal Article

Symptoms and Suffering at the End of Life in Children with Cancer

Cancer is the leading cause of nonaccidental death in childhood.1 There has, however, been little evaluation of the overall experience at the end of life of children who are dying of cancer or of their symptoms other than pain.2,3 A number of studies…

Tags: 2000, Anorexia/etiology/therapy, Backlog, Boston, Child, Children's Hospital (Boston), Clodronate, Constipation/etiology/therapy, Dana-Farber Cancer Institute (Boston), Death and Euthanasia, Diarrhea/etiology/therapy, Dyspnea/etiology/therapy, Ellenbogen JM, Emanuel EJ, Empirical Approach, Fatigue/etiology/therapy, Grier Holcombe E, Health Care Surveys, home care services, Humans, Journal Article, Klar Neil, Levin SB, Logistic Models, Longitudinal Studies, Neoplasms/complications/therapy, New England Journal Of Medicine, Non-U.S. Gov't, Oncology at EOL, P.H.S., Pain/etiology/therapy, Palliative Care/standards/statistics & Numerical Data, Parents, Physicians, Professional Patient Relationship, Psychological, Quality Of Health Care, Quality Of Life, Questionnaires, Research Support, Salem-Schatz S, Stress, Terminal Care, U.S. Gov't, Weeks Jane C, Withholding Treatment, Wolfe J

Browse Items (32 total)