Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

Devogelaer JP; Malghem J; Maldague B; Nagant de Deuxchaisnes C

Skeletal Radiology

1987

Child; Female; Humans; Follow-Up Studies; Clodronate; Diphosphonates/therapeutic use; Osteogenesis Imperfecta/drug therapy/radiography

A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.

1987

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