Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

Title

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

Creator

Devogelaer JP; Malghem J; Maldague B; Nagant de Deuxchaisnes C

Identifier

Publisher

Skeletal Radiology

Date

1987

Subject

Child; Female; Humans; Follow-Up Studies; Clodronate; Diphosphonates/therapeutic use; Osteogenesis Imperfecta/drug therapy/radiography

Description

A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.
1987

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

360-363

Issue

5

Volume

16

Citation

Devogelaer JP; Malghem J; Maldague B; Nagant de Deuxchaisnes C, “Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta,” Pediatric Palliative Care Library, accessed May 23, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12547.

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