Bisphosphonates for treatment of childhood hypercalcemia

Title

Bisphosphonates for treatment of childhood hypercalcemia

Creator

Lteif AN; Zimmerman D

Publisher

Pediatrics

Date

1998

Subject

Child; Female; Humans; Leukemia; adolescent; Preschool; Clodronate; Diphosphonates/therapeutic use; Acute; Lymphocytic; Calcium/blood; Hypercalcemia/drug therapy/etiology; Immobilization/adverse effects; L1/complications

Description

Most clinicians only have a limited experience in treating childhood hypercalcemia with bisphosphonates. We report our experience in the use of intravenous and oral bisphosphonates in a 5-year-old with hypercalcemia secondary to acute lymphocytic leukemia, a 16-year-old with immobilization hypercalcemia, and a 14-year-old with chronic hypercalcemia of unknown cause. Single infusions of 0.5 mg/kg and 1 mg/kg of intravenous pamidronate were administered over 4 hours. No adverse reactions were observed except for hypocalcemia. A dose between 10 and 20 mg of oral alendronate was successfully used to maintain normocalcemia in the patient with chronic hypercalcemia. In our experience, the administration of bisphosphonates has enabled us to achieve normocalcemia in all cases, and in all cases there were no significant side effects. Long-term potential side effects from their use in children during the active phase of growth remain unknown.
1998

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

990-993

Issue

4

Volume

102

Citation

Lteif AN; Zimmerman D, “Bisphosphonates for treatment of childhood hypercalcemia,” Pediatric Palliative Care Library, accessed October 23, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11806.

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