Browse Items · Pediatric Palliative Care Library

Bisphosphonates for the relief of pain secondary to bone metastases

BACKGROUND: Bisphosphonates form part of standard therapy for hypercalcemia and the prevention of skeletal events in some cancers. However, the role of bisphosphonates in pain relief for bony metastases remains uncertain. OBJECTIVES: To determine the…

Tags: 2002, Analgesics, Antineoplastic Agents/therapeutic use, Backlog, Bone Neoplasms/complications/drug therapy/secondary, Clodronate, Clodronic Acid/therapeutic use, Cochrane Database of Systematic Reviews, Diphosphonates/therapeutic use, Etidronic Acid/therapeutic use, Humans, Journal Article, Non-Narcotic/therapeutic use, Pain/drug Therapy, Randomized Controlled Trials, Wiffen PJ, Wong R

Bisphosphonates for cancer patients: why, how, and when?

Bisphosphonates (BPs) are potent inhibitors of osteoclast-mediated bone resorption, and it is well accepted that tumor cells in bone, especially breast cancer and myeloma cells, can stimulate osteoclast formation and activity leading to the release…

Tags: 2002, Backlog, Body JJ, Bone Neoplasms/complications/drug therapy/prevention & control/secondary, Breast Neoplasms/pathology, Diphosphonates/therapeutic use, Female, Humans, Hypercalcemia/etiology/prevention & control, Journal Article, Male, Mancini I, Multiple Myeloma/pathology, Neoplasm Metastasis/prevention & control, Prostatic Neoplasms/pathology, Randomized Controlled Trials, Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer

Modern approach to children with osteogenesis imperfecta

Osteogenesis Imperfecta (OI) is characterized by bone fragility. At least seven discrete types have been described ranging from mild disease to a lethal form. In a large number of cases, mutations in one of the two genes encoding type I collagen have…

Systematic review of bisphosphonates for hypercalcaemia of malignancy

BACKGROUND: Bisphosphonates are the treatment of choice for hypercalcaemia of malignancy (HCM) but there is no consensus regarding which drug or dose should be given. We designed a systematic review to investigate the efficacy of bisphosphonates in…

Tags: 2004, Backlog, Broadley KE, Diphosphonates/therapeutic use, Edmonds PM, Humans, Hypercalcemia/drug therapy, Journal Article, Neoplasms/complications, Non-U.S. Gov't, Palliative Medicine, Patel S, Randomized Controlled Trials, Research Support, Ross JR, Saunders Y, Steering Group, Treatment Outcome

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration…

Tags: 1987, Backlog, Child, Clodronate, Devogelaer JP, Diphosphonates/therapeutic use, Female, Follow-up Studies, Humans, Journal Article, Maldague B, Malghem J, Nagant de Deuxchaisnes C, Osteogenesis Imperfecta/drug therapy/radiography, Skeletal Radiology

Hypercalcaemia in osteogenesis imperfecta treated with pamidronate

The response to the bisphosphonate, pamidronate, is reported in a child with osteogenesis imperfecta who had recurrent symptomatic hypercalcaemia after immobilisation following fractures. Oral clodronate was effective in the prevention of…

Tags: 1997, Adolescent, Archives of Disease in Childhood, Backlog, Ball RJ, Diphosphonates/therapeutic use, Fractures, Humans, Hypercalcemia/drug therapy/etiology, Journal Article, Male, Osteogenesis Imperfecta/complications, Recurrence, Smith RA, Spontaneous/complications, Wilkinson H, Williams CJ

Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care

This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to…

Bisphosphonates for treatment of childhood hypercalcemia

Most clinicians only have a limited experience in treating childhood hypercalcemia with bisphosphonates. We report our experience in the use of intravenous and oral bisphosphonates in a 5-year-old with hypercalcemia secondary to acute lymphocytic…

Browse Items (8 total)