Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates
Title
Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates
Creator
Zacharin M; Cundy T
Identifier
Publisher
The Journal Of Pediatrics
Date
2000
Subject
Child; Female; Humans; Male; Analgesics; Growth; Non-U.S. Gov't; Research Support; Syndrome; Infusions; Intravenous; Clodronate; Pain/prevention & control; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Diphosphonates/administration & dosage; Fractures; Bone Density/physiology; Bone/complications/physiopathology; Osteoporosis/complications/drug therapy/physiopathology; Spine/physiopathology; Vision Disorders/complications
Description
OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis. METHODS: Three children (ages 9 to 11 years) with osteoporosis pseudoglioma syndrome who had multiple vertebral collapse were treated over a 2-year period with intermittent intravenous bisphosphonate infusions (pamidronate in 2, clodronate in 1). The responses to therapy were assessed with clinical and radiographic evaluation and bone densitometry of the spine. RESULTS: All 3 subjects reported early reductions in bone pain and improved mobility. Radiographs showed dense new bone in the vertebral end plates and remodeling of the vertebral bodies. Areal bone mineral density at the lumbar spine (age-appropriate SD score) improved from a mean of -4.5 before treatment to -2.8 after 2 years (P <.05). No new fractures occurred, and side effects were minimal. Growth and pubertal development proceeded normally. CONCLUSIONS: Intravenous bisphosphonate therapy appears safe and beneficial in patients with this condition and may prevent progressive vertebral deformity.
2000
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Zacharin M; Cundy T, “Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates,” Pediatric Palliative Care Library, accessed February 10, 2025, https://pedpalascnetlibrary.omeka.net/items/show/12101.