Diphosphonates: history and mechanisms of action

Title

Diphosphonates: history and mechanisms of action

Creator

Fleisch H

Publisher

Metabolic Bone Disease & Related Research

Date

1981

Subject

Humans; Animals; Non-U.S. Gov't; Research Support; Clodronate; Bone Resorption/drug effects; Calcification; Calcinosis/drug therapy; Calcium Phosphates/metabolism; Clodronic Acid; Diphosphates/pharmacology; Diphosphonates/metabolism/pharmacology/therapeutic use; Etidronic Acid/pharmacology; Methylene Chloride; Physiologic/drug effects; Polyphosphates/pharmacology

Description

The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium phosphate to its crystalline form, and inhibited crystal aggregation and dissolution. These observations suggested that it might be a compound of physiological or pathophysiological significance, perhaps in hypophosphatasia and in renal lithiasis. Diphosphonates are compounds where the P-O-P bond of pyrophosphate is replaced by a P-C-P bond. Many diphosphonates have been synthesized and tested and some relationship of their structure to the spectrum of biological effects has been observed. These analogues have similar properties to pyrophosphate, but unlike pyrophosphate they are resistant to enzymic degradation. Their experimental properties have led to their clinical development as bone scanning agents and in the treatment of disorders of ectopic mineralization and increased bone resorption.
1981

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

279-287

Issue

4

Volume

3

Citation

Fleisch H, “Diphosphonates: history and mechanisms of action,” Pediatric Palliative Care Library, accessed September 23, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12540.

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