Osteoporosis at presentation of childhood ALL: management with pamidronate

Title

Osteoporosis at presentation of childhood ALL: management with pamidronate

Creator

Goldbloom EB; Cummings EA; Yhap M

Publisher

Pediatric Hematology And Oncology

Date

2005

Subject

Child; Female; Humans; Male; Leukemia; Preschool; Clodronate; Acute; Lymphocytic; Bone Density/drug effects; Diphosphonates/administration & dosage; Fractures; Bone Density Conservation Agents/administration & dosage; L1/complications/radiography/therapy; Osteoporosis/drug therapy/etiology/radiography; Spinal Fractures/drug therapy/etiology/radiography; Spontaneous/drug therapy/etiology/radiography

Description

Vertebral fractures at diagnosis of childhood acute lymphoblastic leukemia (ALL) are an uncommon but recognized problem. Clinical issues associated with pathological fractures in these children include pain control and the potential for further treatment-associated fractures and long-term bony morbidity. The authors report the successful use of pamidronate in two children who presented with vertebral compression fractures at diagnosis of ALL. Both patients had pain and low bone mineral density at baseline. In addition to standard chemotherapy, pamidronate (1 mg/kg, IV) was given bimonthly. Initial rapid symptom relief and gradual improvement of bone mineral density was demonstrated in both patients.
2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

543-550

Issue

7

Volume

22

Citation

Goldbloom EB; Cummings EA; Yhap M, “Osteoporosis at presentation of childhood ALL: management with pamidronate,” Pediatric Palliative Care Library, accessed June 25, 2022, https://pedpalascnetlibrary.omeka.net/items/show/13607.

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