New uses of bisphosphonates: osteogenesis imperfecta

Title

New uses of bisphosphonates: osteogenesis imperfecta

Creator

Devogelaer JP

Publisher

Current Opinion in Pharmacology

Date

2002

Subject

Humans; Clodronate; Bone Density/drug effects; Diphosphonates/pharmacology/therapeutic use; Osteogenesis Imperfecta/classification/diagnosis/drug therapy

Description

Osteogenesis imperfecta is a heterogeneous group of inherited disorders chiefly affecting type I collagen, resulting in bone fragility responsible for a host of recurrent fractures. Limb and spine deformities, growth failure and restricted mobility are the end-result in severe cases. Cyclical intermittent intravenous infusions of pamidronate, a potent inhibitor of bone resorption, have yielded substantial improvement in chronic pain, bone mineral density, fracture rate and mobility without significant side effects. The role of growth hormone and bone marrow transplantation in the treatment of osteogenesis imperfecta is still unresolved. Newer, theoretically more potent bisphosphonates are currently being tested in this potentially crippling condition.
2002

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

748-753

Issue

6

Volume

2

Citation

Devogelaer JP, “New uses of bisphosphonates: osteogenesis imperfecta,” Pediatric Palliative Care Library, accessed July 4, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12989.

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