Diphosphonate treatment of Paget's disease
Title
Diphosphonate treatment of Paget's disease
Creator
Finerman GA; Gonick HC; Smith RK; Mayfield JM
Identifier
Publisher
Clinical Orthopaedics and Related Research
Date
1976
Subject
Female; Humans; Male; Aged; Middle Aged; Clodronate; Alkaline Phosphatase/blood; Fractures; Bone/etiology; Diphosphonates/administration & dosage/adverse effects/therapeutic use; Osteitis Deformans/drug therapy/metabolism/radiography; Osteomalacia/etiology; Proline/urine
Description
Ethane-1-hydroxy-1, 1-diphosphonate (EHDP) was administered in a dose of 20 mg/kg/d to 21 patients with symptomatic Paget's disease. All patients were treated for 6 months and then followed for an additional 6 months. There was a striking decline in serum alkaline phosphatase and urinary hydroxy-proline excretion observed after 3 months of therapy which was not significantly improved in the succeeding 3 months. Concomitantly there was marked improvement in clinical symptoms and bone scans. Following cessation of therapy, continued biochemical and clinical evidence of remission persisted. Several patients on repeat treatment with EHDP appeared to respond promptly. Side effects were minimal except for a possibly related osteomalacia and increased incidence of pathologic fractures.
1976
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Finerman GA; Gonick HC; Smith RK; Mayfield JM, “Diphosphonate treatment of Paget's disease,” Pediatric Palliative Care Library, accessed February 9, 2025, https://pedpalascnetlibrary.omeka.net/items/show/12487.