Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care
Title
Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care
Creator
Mannix K; Ahmedzai SH; Anderson H; Bennett M; Lloyd-Williams M; Wilcock A
Identifier
Publisher
Palliative Medicine
Date
2000
Subject
Female; Humans; Male; Evidence-Based Medicine; Practice Guidelines; Palliative Care/standards; Clodronate; Diphosphonates/therapeutic use; Pain/prevention & control; Prostatic Neoplasms; Bone Neoplasms/secondary; Breast Neoplasms; Multiple Myeloma
Description
This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to literature review and grading of clinical evidence. CANCERLIT and Embase were searched for relevant papers written in English, published since 1980. Each study identified was rated against agreed criteria for levels of evidence. Most studies were not specifically designed to define speed of response, and were not undertaken in palliative care patients. Thus, careful reading and grading of each study was necessary. Sufficient evidence was identified to make recommendations for clinical practice in a palliative care population of patients, and areas for future research have been identified. Bisphosphonates appear to have a role in managing pain from metastases which has been refractory to conventional analgesic management and where oncological or orthopaedic intervention is delayed or inappropriate.
2000
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Mannix K; Ahmedzai SH; Anderson H; Bennett M; Lloyd-Williams M; Wilcock A, “Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care,” Pediatric Palliative Care Library, accessed April 25, 2024, https://pedpalascnetlibrary.omeka.net/items/show/11818.