Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care

Title

Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care

Creator

Mannix K; Ahmedzai SH; Anderson H; Bennett M; Lloyd-Williams M; Wilcock A

Publisher

Palliative Medicine

Date

2000

Subject

Female; Humans; Male; Evidence-Based Medicine; Practice Guidelines; Palliative Care/standards; Clodronate; Diphosphonates/therapeutic use; Pain/prevention & control; Prostatic Neoplasms; Bone Neoplasms/secondary; Breast Neoplasms; Multiple Myeloma

Description

This work was undertaken by the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland (APM) as a demonstration project in developing clinical guidelines relevant to palliative care from a pragmatic approach to literature review and grading of clinical evidence. CANCERLIT and Embase were searched for relevant papers written in English, published since 1980. Each study identified was rated against agreed criteria for levels of evidence. Most studies were not specifically designed to define speed of response, and were not undertaken in palliative care patients. Thus, careful reading and grading of each study was necessary. Sufficient evidence was identified to make recommendations for clinical practice in a palliative care population of patients, and areas for future research have been identified. Bisphosphonates appear to have a role in managing pain from metastases which has been refractory to conventional analgesic management and where oncological or orthopaedic intervention is delayed or inappropriate.
2000

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

455-461

Issue

6

Volume

14

Citation

Mannix K; Ahmedzai SH; Anderson H; Bennett M; Lloyd-Williams M; Wilcock A, “Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for palliative care,” Pediatric Palliative Care Library, accessed January 17, 2022, https://pedpalascnetlibrary.omeka.net/items/show/11818.

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