Browse Items · Pediatric Palliative Care Library

Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain

The opioid peptide beta-endorphin (END) as well as mRNA for its precursor proopiomelanocortin (POMC) are found not only in the pituitary gland, but also within various types of immune cells infiltrating inflamed sc tissue. During stressful stimuli…

Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats.

We recently observed that acute systemic hypoxia produces rapid increases in leukocyte adherence in the mesenteric microcirculation of the anesthetized rat Wood JG, Johnson JS, Mattioli LF, and Gonzalez NC. J Appl Physiol 87: 1734-1740, 1999; Wood…

Systemic lidocaine for neuropathic pain relief

The effectiveness of systemic lidocaine in relieving acute and chronic pain has been recognized for over 35 years. In particular, systemic lidocaine has been utilized both as a diagnostic and therapeutic tool for intractable neuropathic pain during…

Tags: 2000, Administration, Analgesics/administration & dosage/diagnostic use/therapeutic use, Animals, Backlog, Chen LL, Humans, Journal Article, Lidocaine/administration & dosage/diagnostic use/therapeutic use, Mao J, Mexiletine/therapeutic use, Neuralgia/drug therapy/metabolism, Oral, P.H.S., Pain, Research Support, Sodium Channel Blockers, U.S. Gov't

The "lactation after infant death (AID) framework": a guide for online health information provision about lactation after stillbirth and infant death

This article collated and critically reviewed international evidence-based lactation and bereavement information to devise a comprehensive framework on the diverse options for lactation management after stillbirth and infant death by outlining the…

The control of pain in peripheral tissue by opioids

1995

Tags: 1995, Afferent/drug effects, Animals, Backlog, Biomarkers of Pain, Humans, Journal Article, Narcotics/therapeutic use, Neurons, Opioid/drug effects, Pain/drug Therapy, Peripheral Nervous System Diseases/drug therapy/physiopathology, Receptors, Stein C, The New England Journal Of Medicine

The final step in programmed cell death: phagocytes carry apoptotic cells to the grave.

As cells undergo apoptosis, they are recognized and removed from the body by phagocytes. This oft-overlooked yet critical final step in the cell-death programme protects tissues from exposure to the toxic contents of dying cells and also serves to…

The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory overview

1999

Tags: 1999, Animals, Annals Of The New York Academy Of Sciences, Backlog, Biomarkers of Pain, Humans, Journal Article, Lipton J, Luger TA, Neuroimmunomodulation/physiology, Paus R, Pro-Opiomelanocortin/physiology, Skin Physiology, Skin/immunology, Slominski A

The role of endogenous opioids and their receptors in the immune system

Opioid peptides appear to be dynamic signaling molecules that are produced within the immune system and are active regulators of an immune response. Furthermore, the receptors for these peptides occurring on immunocyte membranes share characteristics…

Tags: 1991, Animals, Backlog, Biomarkers of Pain, Carr DJ, Endorphins/physiology, Humans, Immune System/physiology, Immunity, Journal Article, Opioid/physiology, Proceedings Of The Society For Experimental Biology And Medicine (New York, N.Y.), Receptors

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have…

Tags: 2011, Animals, Arthritis, Arthritis Research & Therapy, Backlog, Central Nervous System/physiopathology, Chronic Pain/complications/physiopathology, Clauw DJ, Fibromyalgia/complications/physiopathology, Humans, Journal Article, Lee YC, Nassikas NJ, Osteoarthritis/complications/physiopathology, Rheumatoid/complications/physiopathology

Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception

BACKGROUND: Opioid-containing leukocytes migrate to peripheral sites of inflammation. On exposure to stress, opioid peptides are released, bind to opioid receptors on peripheral sensory neurons, and induce endogenous antinociception. In later stages…

Topical and peripherally acting analgesics

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially…

Tags: 2003, Administration, Afferent/drug effects/metabolism/physiology, Analgesics/administration & dosage/pharmacology/therapeutic use, Animals, Backlog, Humans, Journal Article, Neurons, Nociceptors/metabolism/physiology, Non-U.S. Gov't, Pain/drug therapy/metabolism/physiopathology, Peripheral Nervous System/drug effects, Pharmacological Reviews, Research Support, Sawynok J, Signal Transduction/drug effects/physiology, Topical

Trends in incidence, prevalence, and mortality of neuromuscular disease in Ontario, Canada: a population-based retrospective cohort study (2003-2014)

Background: Population trends of disease prevalence and incidence over time measure burden of disease and inform healthcare planning. Neuromuscular disorders (NMD) affect muscle and nerve function with varying degrees of severity and disease…

Tags: 2019, Adolescent, Adult, Age, Aged, America, Amin R, amyotrophic lateral sclerosis, amyotrophic lateral sclerosis/ep [Epidemiology], Animals, APEC countries, Article, August 2019 List, Bai Y, Canada, Child, childhood disease/ep [Epidemiology], childhood diseases, Children, Chordata, Cohort Analysis, Cohort Studies, Commonwealth of Nations, Controlled Study, Data Base, death rate, Developed Countries, Disease Course, disease prevalence, Disease Progression, Eukaryotes, Female, Gershon A, Goldstein R, Health Care, health Insurance, Hominidae, Homo, Human, Human Diseases, Incidence, Infant, International Classification of Diseases, Katz S, Leasa D, Major Clinical Study, Male, Mammals, Man, McKim D, Middle Aged, Mortality, mortality rates, muscles, neuromuscular disease/ep [Epidemiology], Neuromuscular Diseases, Neuromuscular Disorders, Nonoyama M, North America, OECD Countries, Ontario, Palliative Care, Palliative Therapy, planning, PLoS One, Population Research, Preschool Child, Prevalence, Primates, Retrospective Studies, Retrospective Study, Rose L, School Child, sclerosis, spinal muscular atrophy/ep [Epidemiology], Spine, Survival, Tandon A, trend study, Trends, Vertebrates, Young Adult

Tags: 2012, Adrenoleukodystrophy, Animals, ATP-Binding Cassette Transporters, Aubourg P, Backlog, Berger J, Biochimica Et Biophysica Acta, Brain, Fatty Acids, Female, Humans, Journal Article, Kemp S, Mutation, Phenotype, Pregnancy, Prenatal Diagnosis

Browse Items (95 total)