The role of endogenous opioids and their receptors in the immune system

Title

The role of endogenous opioids and their receptors in the immune system

Creator

Carr DJ

Publisher

Proceedings Of The Society For Experimental Biology And Medicine (New York, N.Y.)

Date

1991

Subject

Humans; Animals; Biomarkers of Pain; Receptors; Immune System/physiology; Endorphins/physiology; Opioid/physiology; Immunity

Description

Opioid peptides appear to be dynamic signaling molecules that are produced within the immune system and are active regulators of an immune response. Furthermore, the receptors for these peptides occurring on immunocyte membranes share characteristics with neuronal opioid receptors, including molecular size, immunogenicity, and the use of specific intracellular signaling pathways. Recent studies of the interaction of opioids with cytokines have indicated that opioid peptides are intimately involved within the immune system. Specifically, opioids, including 2-n-pentyloxy-2-phenyl-4-methyl-morpholine, naloxone, and beta-endorphin, have been shown to interact with IL-2 receptors (134) and regulate production of IL-1 and IL-2 (48-50, 135). Conversely, IL-1 has been shown to up-regulate opioid peptide binding in brain tissue (136). Furthermore, the induction of IL-1 by opioids has also been identified in the invertebrate Mytilus, indicating the evolutionary conservation of this relationship (137). These results seem to typify the intricate association between the immune and neuroendocrine systems through opioid pathways. It is predicted that future endeavors will use this relationship to diagnose and treat specific diseases that have at their basis neuroendocrine and immunologic imbalances.
1991

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

710-720

Issue

2

Volume

198

Citation

Carr DJ, “The role of endogenous opioids and their receptors in the immune system,” Pediatric Palliative Care Library, accessed January 17, 2022, https://pedpalascnetlibrary.omeka.net/items/show/11751.

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