Browse Items · Pediatric Palliative Care Library

Pediatric utilization of rapamycin for severe cardiac allograft rejection

BACKGROUND: Rapamycin is a new immunosuppressive agent that has been shown to be effective in the treatment of acute cardiac rejection in the adult population. METHODS: This case documents a pediatric patient with ongoing cardiac rejection that did…

The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory overview

1999

Tags: 1999, Animals, Annals Of The New York Academy Of Sciences, Backlog, Biomarkers of Pain, Humans, Journal Article, Lipton J, Luger TA, Neuroimmunomodulation/physiology, Paus R, Pro-Opiomelanocortin/physiology, Skin Physiology, Skin/immunology, Slominski A

Proopiomelanocortin and the immune-neuroendocrine connection

This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular…

Tags: 1999, Amino Acid Sequence, Animals, Annals Of The New York Academy Of Sciences, Backlog, Base Sequence, Biomarkers of Pain, Biomarkers Reference List, Blalock JE, Humans, Immune System/physiology, Interleukin-1/physiology, Journal Article, Molecular Sequence Data, Neuroimmunomodulation/physiology, Neurosecretory Systems/physiology, Pro-Opiomelanocortin/genetics/physiology

Contractile mechanisms of action of gastroprokinetic agents: cisapride, metoclopramide, and domperidone

We investigated the contractile mechanisms of action of three putative gastroprokinetic agents (cisapride, metoclopramide, and domperidone) on the linear phase of gastroduodenal emptying of solid meals in six healthy conscious dogs. The spatial and…

Chronic hypoxia selectively augments rat pulmonary artery Ca2+ and K+ channel-mediated relaxation.

The initiating event in hypoxic pulmonary hypertension is felt to be sustained hypoxic vasoconstriction, ultimately leading to vascular remodeling and fixed pulmonary hypertension. During the initial vasospastic phase endogenous vasodilatory pathways…

Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats.

We recently observed that acute systemic hypoxia produces rapid increases in leukocyte adherence in the mesenteric microcirculation of the anesthetized rat Wood JG, Johnson JS, Mattioli LF, and Gonzalez NC. J Appl Physiol 87: 1734-1740, 1999; Wood…

Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats

Localized inflammation of a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing immune cells. We investigated the production, release, and antinociceptive effects of lymphocyte-derived END in relation to cell trafficking. In…

What do we know about the expression of proopiomelanocortin transcripts and related peptides in lymphoid tissue?

1993

Tags: 1993, Animals, Backlog, Biomarkers of Pain, Endocrinology, Humans, Journal Article, Linner K, Lymphoid Tissue/metabolism, Messenger/metabolism, Pro-Opiomelanocortin/genetics, RNA, Sharp B

Bisphosphonates: mechanisms of action

1998

Tags: 1998, Animals, Backlog, Bone Development/drug effects, Bone Resorption/physiopathology, Clodronate, Diphosphonates/chemistry/metabolism/pharmacology, Endocrine Reviews, Fleisch H, Humans, Journal Article

Metabolic alterations in dogs with osteosarcoma

OBJECTIVE: To evaluate changes in resting energy expenditure (REE) as well as protein and carbohydrate metabolism in dogs with osteosarcoma (OSA). ANIMALS: 15 weight-stable dogs with OSA that did not have other concurrent metabolic or endocrine…

The role of endogenous opioids and their receptors in the immune system

Opioid peptides appear to be dynamic signaling molecules that are produced within the immune system and are active regulators of an immune response. Furthermore, the receptors for these peptides occurring on immunocyte membranes share characteristics…

Tags: 1991, Animals, Backlog, Biomarkers of Pain, Carr DJ, Endorphins/physiology, Humans, Immune System/physiology, Immunity, Journal Article, Opioid/physiology, Proceedings Of The Society For Experimental Biology And Medicine (New York, N.Y.), Receptors

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have…

Tags: 2011, Animals, Arthritis, Arthritis Research & Therapy, Backlog, Central Nervous System/physiopathology, Chronic Pain/complications/physiopathology, Clauw DJ, Fibromyalgia/complications/physiopathology, Humans, Journal Article, Lee YC, Nassikas NJ, Osteoarthritis/complications/physiopathology, Rheumatoid/complications/physiopathology

X-linked adrenoleukodystrophy: clinical, metabolic, genetic and pathophysiological aspects

X-linked adrenoleukodystrophy (X-ALD) is the most frequent peroxisomal disease. The two main clinical phenotypes of X-ALD are adrenomyeloneuropathy (AMN) and inflammatory cerebral ALD that manifests either in children or more rarely in adults. About…

Tags: 2012, Adrenoleukodystrophy, Animals, ATP-Binding Cassette Transporters, Aubourg P, Backlog, Berger J, Biochimica Et Biophysica Acta, Brain, Fatty Acids, Female, Humans, Journal Article, Kemp S, Mutation, Phenotype, Pregnancy, Prenatal Diagnosis

Association of mortality with the death of a sibling in childhood

Importance: The death of a close relative is associated with an increased mortality risk among the bereaved, but much less is known about the potential association of the death of a sibling in childhood with mortality in this population. Objective:…

Directives of adequacy of the therapeutic effort in children. Experience of the Pediatric Palliative Care Unit of Pereira Rossell Hospital Center (2009-2015)

Introduction: In certain patients, "directives on the adequacy of therapeutic effort" (DAET) known as advanced care planning are important tools to align medical care to patient's and family's objectives of care. Purpose: To describe characteristics…

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