Browse Items · Pediatric Palliative Care Library

Beta-Endorphin Response to an Acute Pain Stimulus

The timing of the measurement of biological samples (e.g. biomarkers) is not always standardized. Biomarkers are the focus of many recent studies and treatments. The purpose of this study was to determine the timing of the release of beta-endorphin…

Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides

There is conflicting evidence on the antinociceptive effects of corticotropin-releasing factor (CRF) along the neuraxis of pain transmission and the responsible anatomical sites of CRF's action at the level of the brain, spinal cord and periphery. In…

Neuroendocrinology of social behavior

Discovering the hormonal and neural mechanisms that promote affiliative social behavior is a high priority in behavioral neuroscience. Although studies with standard laboratory rodents have afforded many important insights, exciting advances are also…

Tags: 2009, Adkins-Regan E, Animal, Animals, Arvicolinae/physiology, Backlog, Behavior, Female, Finches/physiology, Gonadal Steroid Hormones/physiology, Hypothalamo-Hypophyseal System/physiology, ILAR Journal, Journal Article, Male, Neuropeptides/physiology, Neurosecretory Systems/physiology, Oxytocin/physiology, Pair Bond, Social Behavior

Beta-endorphin mediates behavioral despair and the effect of ethanol on the tail suspension test in mice.

Background: The opioid peptide beta-endorphin (beta-E) is synthesized and released in response to stressful stimuli as well as acute alcohol administration. The release of beta-E following exposure to an inescapable aversive situation may mediate…

Hypothalamo-pituitary-adrenal axis and chronic immune activation

Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of…

Tags: 2003, Animal, Animals, Annals Of The New York Academy Of Sciences, Autoimmune Diseases/immunology/physiopathology, Backlog, Chover-Gonzalez AJ, Corticosterone/secretion, Disease Models, Harbuz MS, Humans, Hypothalamo-Hypophyseal System/physiopathology, Immune System Diseases/physiopathology, Inflammation/immunology/physiopathology, Jessop DS, Journal Article, Pituitary-Adrenal System/physiopathology, Stress/immunology

Can we conquer pain?

Pain can be an adaptive sensation, an early warning to protect the body from tissue injury. By the introduction of hypersensitivity to normally innocuous stimuli, pain may also aid in repair after tissue damage. Pain can also be maladaptive,…

Tags: 2002, Afferent Pathways/drug effects/metabolism/physiopathology, Analgesics/pharmacology, Animal, Backlog, Biomarkers of Pain, Cell Surface/drug effects/metabolism, Central Nervous System/drug effects/metabolism/physiopathology, Drug Design, Human, Journal Article, Nature Neuroscience, Nociceptors/drug effects/metabolism, Pain/drug therapy/metabolism/physiopathology, Receptors, Scholz J, Signal Transduction/drug effects/physiology, Synaptic Transmission/drug effects/physiology, Woolf CJ

Benzodiazepine dependence and withdrawal: a review of the syndrome and its clinical management

The treatment of anxiety has evolved through various phases. Currently, there is a growing recognition that anxiety disorders are frequently chronic and/or recurrent. There is also less optimism than a decade ago that benzodiazepines will be replaced…

Neuronal plasticity: increasing the gain in pain

We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain. Multiple mechanisms contribute, each of which…

Neurodegenerative disease: the neuronal ceroid lipofuscinoses (Batten disease)

In the past decade there have been significant advances in our understanding of the molecular genetic basis of the neuronal ceroid lipofuscinoses, a clinically and genetically heterogeneous group of childhood neurodegenerative storage disorders.…

Tags: 2001, Animal, Backlog, Child, Chromosome Mapping, Current Opinion in Neurology, Genetic, Genotype, Human, Infant, Journal Article, Membrane Proteins/genetics, Mitchison HM, Models, Mole SE, Neuronal Ceroid-Lipofuscinosis/diagnosis/genetics/therapy, Phenotype, Phosphoprotein Phosphatase/genetics, Proteins/genetics

Browse Items (9 total)