Neuronal plasticity: increasing the gain in pain

Title

Neuronal plasticity: increasing the gain in pain

Creator

Woolf CJ; Salter MW

Publisher

Science

Date

2000

Subject

Models; Human; Signal Transduction; Neurological; Inflammation/physiopathology; Animal; Nociceptors/physiology; Neurons; Pain/physiopathology; Neuronal Plasticity; Afferent/physiology; Peripheral Nerves/injuries; Posterior Horn Cells/physiology; Synaptic Transmission

Description

We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain. Multiple mechanisms contribute, each of which is subject to or an expression of neural plasticity-the capacity of neurons to change their function, chemical profile, or structure. Here, we develop a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain, identifying distinct forms of plasticity, which we term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
2000

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

1765-9

Issue

5472

Volume

288

Citation

Woolf CJ; Salter MW, “Neuronal plasticity: increasing the gain in pain,” Pediatric Palliative Care Library, accessed September 28, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11665.

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