Hypothalamo-pituitary-adrenal axis and chronic immune activation

Title

Hypothalamo-pituitary-adrenal axis and chronic immune activation

Creator

Harbuz MS; Chover-Gonzalez AJ; Jessop DS

Publisher

Annals Of The New York Academy Of Sciences

Date

2003

Subject

Humans; Animals; Inflammation/immunology/physiopathology; Animal; Disease Models; Stress/immunology; Autoimmune Diseases/immunology/physiopathology; Corticosterone/secretion; Hypothalamo-Hypophyseal System/physiopathology; Immune System Diseases/physiopathology; Pituitary-Adrenal System/physiopathology

Description

Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s, a hypothesis was proposed that suggested that susceptibility to autoimmune disease was linked to a hypoactive hypothalamo-pituitary-adrenal (HPA) axis. It was further suggested that this defect in regulation of the HPA axis was situated at the level of the hypothalamus. This compelling hypothesis directly linked control of the HPA axis with susceptibility to disease rather than just severity of inflammation. The initial findings acted as a stimulus to further research, and over the next decade the hypothesis was tested. Recent studies suggest that the original hypothesis is in need of modification and that susceptibility is more complex and requires the involvement of more than a single parameter. These data are discussed together with recent developments concerning regulation of the HPA in disease in preclinical models and patients with rheumatoid arthritis. The latter studies in patients with rheumatoid arthritis provide evidence for the existence of a subpopulation of these patients with altered negative feedback regulation of the HPA axis.
2003

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

99-106

Volume

992

Citation

Harbuz MS; Chover-Gonzalez AJ; Jessop DS, “Hypothalamo-pituitary-adrenal axis and chronic immune activation,” Pediatric Palliative Care Library, accessed January 18, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12770.

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