Gabapentin Successfully Manages Chronic Unexplained Irritability in Children With Severe Neurologic Impairment

Title

Gabapentin Successfully Manages Chronic Unexplained Irritability in Children With Severe Neurologic Impairment

Creator

Hauer JM; Wical BS; Charnas L

Publisher

Pediatrics

Date

2007

Subject

Child; Female; Humans; Male; Adult; Severity of Illness Index; adolescent; Preschool; infant; Chronic disease; retrospective studies; Nervous System Diseases/complications; Analgesics/therapeutic use; Amines/therapeutic use; Cyclohexanecarboxylic Acids/therapeutic use; gamma-Aminobutyric Acid/therapeutic use; Irritable Mood/drug effects; Remission Induction

Description

Neurologically impaired children have an increased frequency of recurrent pain and irritability that persist in some despite comprehensive evaluation and management of possible pain sources. We hypothesized that visceral hyperalgesia was a source of chronic unexplained irritability and report the outcome of gabapentin treatment in 9 severely neurologically impaired children. Caregivers reported marked improvement after treatment ranging from 3 months to 3 years. Nystagmus in 1 child was the only noted adverse effect. Visceral hyperalgesia may be a source of unexplained irritability in the neurologically impaired child. Symptoms may improve with gabapentin treatment.
2007-02

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

e519-e522

Issue

2

Volume

119

Citation

Hauer JM; Wical BS; Charnas L, “Gabapentin Successfully Manages Chronic Unexplained Irritability in Children With Severe Neurologic Impairment,” Pediatric Palliative Care Library, accessed September 20, 2021, https://pedpalascnetlibrary.omeka.net/items/show/13907.

Social Bookmarking