Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit

Title

Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit

Creator

Joffre C; Lesage F; Bustarret O; Hubert P; Oualha M

Identifier

Publisher

Journal Of Paediatrics And Child Health

Date

2016

Subject

Hospitalization; Intensive Care Units Pediatric; Adolescent; Child; Child Preschool; Critical Illness/ Mortality; Critically Ill Children; Down Syndrome; Down Syndrome/ Complications/ Mortality; Female; Hospital Mortality; Humans; Infant; Male; Mortality; Retrospective Studies

Description

AIM: To investigate clinical course and mortality-associated factors in children with Down syndrome (DS) managed in a medical paediatric intensive care unit. METHODS: A single-centre, retrospective study conducted between 2001 and 2010 in DS children aged 1 month to 16 years. RESULTS: Sixty-six patients with a median age of 24 months (1-192) and a male/female ratio of 1.5 were analysed. Patients presented with history of congenital heart disease (n = 52, 78.8%), mechanical ventilation (n = 40, 60.6%) and chronic upper airway obstruction (n = 10, 15.1%). The primary reason for admission was respiratory failure (n = 56, 84.8%). Pulmonary arterial hypertension (PAH) (n = 19, 28.8%), acute respiratory distress syndrome (ARDS) (n = 18, 27.2%) and sepsis (n = 14, 21.2%) were observed during their clinical course. Twenty-six patients died (39.4%). Mortality-associated factors included the following: (i) baseline characteristics: history of mechanical ventilation, chronic upper airway obstruction and congenital heart disease; (ii) clinical course during paediatric intensive care unit stay: sepsis, catecholamine support, ARDS, PAH and nosocomial infection. In multivariate logistic analysis, history of mechanical ventilation, ARDS and PAH remained independently associated with death. CONCLUSIONS: The mortality rate in critically ill DS children admitted for medical reasons is high and is predominantly associated with respiratory conditions.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation List Month

November 2017 List

Notes

1440-1754
Joffre, Christelle
Lesage, Fabrice
Bustarret, Olivier
Hubert, Philippe
Oualha, Mehdi
Journal Article
Australia
J Paediatr Child Health. 2016 Jun;52(6):595-9. doi: 10.1111/jpc.13214.

Citation

Joffre C; Lesage F; Bustarret O; Hubert P; Oualha M, “Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit,” Pediatric Palliative Care Library, accessed November 28, 2021, https://pedpalascnetlibrary.omeka.net/items/show/11039.

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