Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit
Title
Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit
Creator
Joffre C; Lesage F; Bustarret O; Hubert P; Oualha M
Identifier
Publisher
Journal Of Paediatrics And Child Health
Date
2016
Subject
Hospitalization; Intensive Care Units Pediatric; Adolescent; Child; Child Preschool; Critical Illness/ Mortality; Critically Ill Children; Down Syndrome; Down Syndrome/ Complications/ Mortality; Female; Hospital Mortality; Humans; Infant; Male; Mortality; Retrospective Studies
Description
AIM: To investigate clinical course and mortality-associated factors in children with Down syndrome (DS) managed in a medical paediatric intensive care unit. METHODS: A single-centre, retrospective study conducted between 2001 and 2010 in DS children aged 1 month to 16 years. RESULTS: Sixty-six patients with a median age of 24 months (1-192) and a male/female ratio of 1.5 were analysed. Patients presented with history of congenital heart disease (n = 52, 78.8%), mechanical ventilation (n = 40, 60.6%) and chronic upper airway obstruction (n = 10, 15.1%). The primary reason for admission was respiratory failure (n = 56, 84.8%). Pulmonary arterial hypertension (PAH) (n = 19, 28.8%), acute respiratory distress syndrome (ARDS) (n = 18, 27.2%) and sepsis (n = 14, 21.2%) were observed during their clinical course. Twenty-six patients died (39.4%). Mortality-associated factors included the following: (i) baseline characteristics: history of mechanical ventilation, chronic upper airway obstruction and congenital heart disease; (ii) clinical course during paediatric intensive care unit stay: sepsis, catecholamine support, ARDS, PAH and nosocomial infection. In multivariate logistic analysis, history of mechanical ventilation, ARDS and PAH remained independently associated with death. CONCLUSIONS: The mortality rate in critically ill DS children admitted for medical reasons is high and is predominantly associated with respiratory conditions.
Rights
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Citation List Month
November 2017 List
Notes
1440-1754
Joffre, Christelle
Lesage, Fabrice
Bustarret, Olivier
Hubert, Philippe
Oualha, Mehdi
Journal Article
Australia
J Paediatr Child Health. 2016 Jun;52(6):595-9. doi: 10.1111/jpc.13214.
Citation
Joffre C; Lesage F; Bustarret O; Hubert P; Oualha M, “Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit,” Pediatric Palliative Care Library, accessed April 26, 2024, https://pedpalascnetlibrary.omeka.net/items/show/11039.