Opioids

Title

Opioids

Creator

Zollner C; Stein C

Publisher

Handbook Of Experimental Pharmacology

Date

2007

Subject

Humans; Analgesics; Animals; Molecular Sequence Data; Chronic disease; Biomarkers of Pain; Drug Tolerance; Receptors; Amino Acid Sequence; Ligands; Opioid/adverse effects/pharmacology/therapeutic use; Opioid/drug effects

Description

Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (mu, delta, kappa) have been identified. Multiple pathways ofopioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca++ channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
2007

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

31-63

Issue

177

Volume

-177

Citation

Zollner C; Stein C, “Opioids,” Pediatric Palliative Care Library, accessed August 4, 2021, https://pedpalascnetlibrary.omeka.net/items/show/14438.

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