Use of methadone in the morphine-tolerant burned paediatric patient
Title
Use of methadone in the morphine-tolerant burned paediatric patient
Creator
Williams PI; Sarginson RE; Ratcliffe JM
Identifier
Publisher
British Journal Of Anaesthesia
Date
1998
Subject
Child; Female; Humans; Analgesics; Respiration; Methadone; Morphine; infant; Drug Tolerance; Opioid; Artificial; Burns/therapy; Conscious Sedation/methods; Intensive Care/methods
Description
We describe the successful use of methadone in the restoration of sedation and provision of analgesia in two morphine-tolerant, paediatric patients who had suffered significant thermal injuries and were undergoing mechanical ventilation. Both patients had exhibited escalating requirements for sedative drugs while undergoing ventilation yet remained inadequately sedated. The introduction of i.v. methadone in place of i.v. morphine in the sedative regimen rapidly and effectively restored a state of sedation. Hyperalgesia and morphine tolerance appear to be associated; it is proposed that methadone acts primarily, under these circumstances, by re-establishing the analgesic state. Such use of methadone in the morphine-tolerant patient also afforded a concomitant sedative-sparing effect.
1998
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Williams PI; Sarginson RE; Ratcliffe JM, “Use of methadone in the morphine-tolerant burned paediatric patient,” Pediatric Palliative Care Library, accessed April 27, 2024, https://pedpalascnetlibrary.omeka.net/items/show/12045.