Use of methadone in the morphine-tolerant burned paediatric patient

Title

Use of methadone in the morphine-tolerant burned paediatric patient

Creator

Williams PI; Sarginson RE; Ratcliffe JM

Identifier

Publisher

British Journal Of Anaesthesia

Date

1998

Subject

Child; Female; Humans; Analgesics; Respiration; Methadone; Morphine; infant; Drug Tolerance; Opioid; Artificial; Burns/therapy; Conscious Sedation/methods; Intensive Care/methods

Description

We describe the successful use of methadone in the restoration of sedation and provision of analgesia in two morphine-tolerant, paediatric patients who had suffered significant thermal injuries and were undergoing mechanical ventilation. Both patients had exhibited escalating requirements for sedative drugs while undergoing ventilation yet remained inadequately sedated. The introduction of i.v. methadone in place of i.v. morphine in the sedative regimen rapidly and effectively restored a state of sedation. Hyperalgesia and morphine tolerance appear to be associated; it is proposed that methadone acts primarily, under these circumstances, by re-establishing the analgesic state. Such use of methadone in the morphine-tolerant patient also afforded a concomitant sedative-sparing effect.
1998

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

92-95

Issue

1

Volume

80

Citation

Williams PI; Sarginson RE; Ratcliffe JM, “Use of methadone in the morphine-tolerant burned paediatric patient,” Pediatric Palliative Care Library, accessed December 8, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12045.

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