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Tags: Williams DG

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Codeine phosphate in paediatric medicine

2001

Tags: 2001, Analgesics, Backlog, British Journal Of Anaesthesia, Child, Codeine/pharmacokinetics/pharmacology/therapeutic use, Hatch DJ, Howard RF, Human, Journal Article, Non-U.S. Gov't, Opioid/pharmacokinetics/pharmacology/therapeutic use, Pain, Postoperative/drug therapy, Support, Williams DG

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability

BACKGROUND: Codeine analgesia is wholly or mostly due to its metabolism to morphine by the cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The aims of this study were to investigate genotype, phenotype and…

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