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Tags: 2002, Analgesics, Backlog, Biological Availability, Dosage Forms, Drug Administration Schedule, Drug Interactions, Goode JV, Half-Life, Humans, Journal Article, Journal of Pain and Palliative Care Pharmacotherapy, Kidney Diseases/metabolism, Layson-Wolf C, Liver Diseases/metabolism, Methadone/adverse effects/pharmacokinetics/therapeutic use, Opioid-Related Disorders/drug therapy, Opioid/adverse effects/pharmacokinetics/therapeutic use, Opioid/agonists, Pain/drug Therapy, Receptors, Small RE, Substance Withdrawal Syndrome/etiology, Therapeutic Equivalency