Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: an institutional review

Title

Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: an institutional review

Creator

Stanelle EJ; Christison-Lagay ER; Wolden SL; Meyers PA; La Quaglia MP

Publisher

Journal Of Pediatric Surgery

Date

2013

Subject

adolescent; Child; Female; Humans; infant; retrospective studies; Survival Rate; Young Adult; Treatment Outcome; Lung Neoplasms; Preschool; Metastasectomy; Reoperation; Sarcoma; Synovial

Description

PURPOSE: Synovial sarcoma (SS) often metastasizes to the lung; however, the indications for and outcomes of pulmonary metastasectomy have not been evaluated in pediatric/adolescent patients. METHODS: The records of pediatric patients (age <22years) with pathologically confirmed SS and pulmonary metastasis treated between June 1971 and May 2011 at our institution were retrospectively reviewed for the number and type of surgical metastasectomies, tumor characteristics, and survival outcomes. RESULTS: Forty-one patients (mean age: 15.9years) were identified and 31 (76%) underwent at least one metastasectomy. Seventy-two resections (range, 1-8/patient) were performed. Two- and 5-year survival rates after metastasis diagnosis were 65% and 24% for patients who underwent metastasectomy. Patients who did not undergo a metastasectomy survived no more than 2years from the diagnosis of pulmonary disease (P<0.001). Longer time to progression after primary tumor resection (>1year) and complete resection of pulmonary disease correlated with greater OS (P=0.02 and P<0.001, respectively). Palliative debulking did not improve OS. Survival was unaffected by tumor histological subtype, bilateral pulmonary disease, number of surgical resections, or number and size of resected metastatic lesions. CONCLUSION: Pulmonary metastasectomy may be associated with improved survival in pediatric/adolescent patients with SS and pulmonary metastases if complete resection is achieved.
2013-04

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

757-763

Issue

4

Volume

48

Citation

Stanelle EJ; Christison-Lagay ER; Wolden SL; Meyers PA; La Quaglia MP, “Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: an institutional review,” Pediatric Palliative Care Library, accessed October 18, 2021, https://pedpalascnetlibrary.omeka.net/items/show/14749.

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