Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome)

Title

Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome)

Creator

Mumford R A; Mahon L V; Jones S; Bigger B; Canal M; Hare D J

Publisher

Journal of Neurodevelopmental Disorders

Date

2015

Subject

Actigraphy; Sleep; rare disease; Neurosciences & Neurology; controlled-trial; intellectual disability; disturbance; melatonin; autistic spectrum disorders; Circadian rhythms; light; Mucopolysaccharidosis type III; multiple disabilities; Sanfilippo; sleep problems; smith-magenis-syndrome; therapy; sleep disturbance/disorders; MPSIIIA; MPSIIIB; trajectory; characteristics

Description

Background: Sleep disturbance is part of the behavioural phenotype of the rare genetic condition mucopolysaccharidosis (MPS) type III. A growing body of evidence suggests that underlying disturbance in circadian rhythm functioning may explain sleep problems within the MPS III population. Methods: Actigraphic data were recorded in eight children with MPS III over 7-10 days and compared to age-matched typically developing controls. Parameters of circadian rhythmicity and activity levels across a 24-h period were analysed. Results: Statistically and clinically significant differences between the two groups were noted. Analysis indicated that children with MPS III showed significantly increased fragmentation of circadian rhythm and reduced stability with external cues (zeitgebers), compared to controls. Average times of activity onset and offset were indicative of a phase delayed sleep-wake cycle for some children in the MPS III group. Children with MPS III had significantly higher activity levels during the early morning hours (midnight-6 am) compared to controls. Conclusions: Results are consistent with previous research into MPS III and suggest that there is an impairment in circadian rhythm functioning in children with this condition. Implications for clinical practice and the management of sleep difficulties are discussed.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Mumford R A; Mahon L V; Jones S; Bigger B; Canal M; Hare D J, “Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome),” Pediatric Palliative Care Library, accessed July 29, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16757.

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