Brain damage markers in children. Neurobiological and clinical aspects

Brain damage markers in children. Neurobiological and clinical aspects

Leviton A; Dammann O

Acta Paediatrica

2002

Child; Female; Humans; Male; Prognosis; Sensitivity and Specificity; Predictive Value of Tests; Nerve Growth Factors; Preschool; Brain Damage; Biological Markers/blood; Brain Injuries/blood/diagnosis; Chronic/blood/diagnosis; Glial Fibrillary Acidic Protein/blood; Phosphopyruvate Hydratase/blood; S100 Proteins/blood

The presence in blood of proteins normally confined to the cytoplasm of brain cells is considered peripheral evidence of brain damage. Only recently have these proteins been measured in the blood of children at risk of brain damage. To show the value and limitations of measuring these proteins, we review their biology and the adult literature that has correlated the blood concentrations of these proteins with lesion size and dysfunction. Conclusion: We conclude that brain damage markers will increasingly be measured in the blood of newborns and other children at risk of brain damage.

2002

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