Endogenous opioid activity in clinical hemorrhagic shock

Title

Endogenous opioid activity in clinical hemorrhagic shock

Creator

Shatney CH; Cohen RM; Cohen MR; Imagawa DK

Publisher

Surgery, Gynecology & Obstetrics

Date

1985

Subject

Female; Humans; Male; Adult; Aged; Middle Aged; Blood Pressure; adolescent; Biomarkers of Pain; Radioimmunoassay; Wounds; Hydrocortisone/blood; Accidents; Endorphins/blood/metabolism; Hemorrhagic/blood/etiology/physiopathology; Nonpenetrating/blood/etiology/physiopathology; Shock; Traffic; Trauma Centers

Description

Plasma beta-endorphin, cortisol and total opioid-like activities were measured upon arrival at the hospital in ten patients with extensive trauma and in a state of shock and 11 patients with minor injury. Patients in a state of shock had significantly (p less than 0.01) higher mean plasma beta-endorphin immunoreactivity than patients with minor trauma (128.8 +/- 24.8 picomolars versus 31.7 +/- 5.6 picomolars). There were no significant intergroup differences in the mean plasma cortisol concentration (27.7 +/- 4.7 micrograms per deciliter versus 20.6 +/- 2.7 micrograms per deciliter) or opioid ligand activity (2.28 +/- 0.62 nanomolars versus 3.17 +/- 0.99 nanomolars). These data are consistent with the hypothesis that certain endogenous opioids may be physiopathologic factors in hemorrhagic shock but provide no proof of a cause and effect relationship.
1985

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

547-551

Issue

6

Volume

160

Citation

Shatney CH; Cohen RM; Cohen MR; Imagawa DK, “Endogenous opioid activity in clinical hemorrhagic shock,” Pediatric Palliative Care Library, accessed September 28, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12474.

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