T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa

T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa

Brambilla F; Brunetta M; Peirone A; Perna G; Sacerdote P; Manfredi B; Panerai AE

Psychiatry Research

1995

Child; Female; Humans; Adult; Treatment Outcome; Combined Modality Therapy; adolescent; Comparative Study; beta-Endorphin/blood; Cognitive Therapy; Anorexia Nervosa/blood/therapy; Antidepressive Agents/administration & dosage; Dibenzocycloheptenes/administration & dosage; Fluoxetine/administration & dosage; Nortriptyline/administration & dosage; Sincalide/blood; T-Lymphocytes/drug effects/metabolism

Baseline concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) were measured in T-lymphocytes from 33 restricting patients with anorexia nervosa (AN-R), 23 binging/purging patients with anorexia nervosa (AN-BP), and 24 healthy volunteers. CCK-8 basal values were significantly lower and beta-EP values significantly higher in AN-R and AN-BP patients than in normal volunteers. Levels of the peptides were measured three more times during a 4-month combined cognitive-behavioral/psychopharmacological treatment (nortriptyline or fluoxetine in AN-R, fluoxetine or amineptine in AN-BP). CCK-8 values fluctuated (nonsignificantly) during each treatment, while beta-EP values decreased (to a significant degree only in fluoxetine-treated AN-R patients).

1995

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