T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II. Bulimia nervosa

T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II. Bulimia nervosa

Brambilla F; Brunetta M; Draisci A; Peirone A; Perna G; Sacerdote P; Manfredi B; Panerai AE

Psychiatry Research

1995

Female; Humans; Adult; Middle Aged; Treatment Outcome; Antidepressive Agents; Combined Modality Therapy; adolescent; Comparative Study; beta-Endorphin/blood; Cognitive Therapy; Dibenzocycloheptenes/administration & dosage; Sincalide/blood; T-Lymphocytes/drug effects/metabolism; Bulimia/blood/therapy; Fluvoxamine/administration & dosage; Serotonin Uptake Inhibitors/administration & dosage; Tricyclic/administration & dosage

Concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline beta-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy.

1995

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