Toxicity of local anesthetics in infants and children
Title
Toxicity of local anesthetics in infants and children
Creator
Berde CB
Identifier
Publisher
The Journal Of Pediatrics
Date
1993
Subject
Child; Humans; Risk Factors; Anesthetics; infant; Absorption; Local/administration & dosage/adverse effects/blood/pharmacokinetics/pharmacology
Description
Local anesthetics are extremely useful for providing anesthesia and analgesia for infants and children of all ages. Despite the toxicity issues raised here, the overall safety record of local anesthetic use in pediatrics has been very good, and local anesthetic administration within safe guidelines should be encouraged. In the great majority of cases, toxic reactions have been associated with either inadvertent intravascular injection or unintentional overdosage by physicians who did not adequately consider issues related to systemic drug uptake, distribution, or clearance. Unlike opioids, which can be titrated according to clinical signs to a wide range of doses, local anesthetic administration must be strictly limited "by the numbers." Pediatricians, surgeons, emergency room physicians, and anesthesiologists need to be informed regarding limits for the administration of local anesthetics and management of toxic reactions.
1993
Rights
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Berde CB, “Toxicity of local anesthetics in infants and children,” Pediatric Palliative Care Library, accessed February 16, 2025, https://pedpalascnetlibrary.omeka.net/items/show/12259.