Pain control by immune-derived opioids
Title
Pain control by immune-derived opioids
Creator
Machelska H; Stein C
Identifier
Publisher
Clinical And Experimental Pharmacology & Physiology
Date
2000
Subject
Humans; Analgesics; Biomarkers of Pain; Receptors; Opioid/therapeutic use; Neuropeptides/therapeutic use; Opioid/drug effects/immunology; Pain/drug therapy/immunology; Peripheral Nervous System/drug effects
Description
1. The nervous and immune systems communicate with each other by use of cytokines and neuropeptides. 2. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. 3. In addition to their immunological functions, immunocytes are involved in intrinsic pain inhibition. This provides new insights into pain associated with a compromised immune system, as in AIDS or in cancer. 4. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards events in peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.
2000
Rights
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Type
Journal Article
Citation List Month
Backlog
URL Address
Citation
Machelska H; Stein C, “Pain control by immune-derived opioids,” Pediatric Palliative Care Library, accessed September 18, 2024, https://pedpalascnetlibrary.omeka.net/items/show/12142.