Pain control by immune-derived opioids

Title

Pain control by immune-derived opioids

Creator

Machelska H; Stein C

Publisher

Clinical And Experimental Pharmacology & Physiology

Date

2000

Subject

Humans; Analgesics; Biomarkers of Pain; Receptors; Opioid/therapeutic use; Neuropeptides/therapeutic use; Opioid/drug effects/immunology; Pain/drug therapy/immunology; Peripheral Nervous System/drug effects

Description

1. The nervous and immune systems communicate with each other by use of cytokines and neuropeptides. 2. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. 3. In addition to their immunological functions, immunocytes are involved in intrinsic pain inhibition. This provides new insights into pain associated with a compromised immune system, as in AIDS or in cancer. 4. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards events in peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.
2000

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

533-536

Issue

7

Volume

27

Citation

Machelska H; Stein C, “Pain control by immune-derived opioids,” Pediatric Palliative Care Library, accessed May 22, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12142.

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