Beta-endorphin and cholecystokinin 8 concentrations in peripheral blood mononuclear cells of autistic children

Beta-endorphin and cholecystokinin 8 concentrations in peripheral blood mononuclear cells of autistic children

Brambilla F; Guareschi-Cazzullo A; Tacchini C; Musetti C; Panerai AE; Sacerdote P

Neuropsychobiology

1997

Child; Female; Humans; Male; Reference Values; adolescent; Preschool; infant; beta-Endorphin/blood; Biomarkers of Pain; Child Development Disorders; Sincalide/blood; Monocytes/metabolism; Autistic Disorder/blood/diagnosis/psychology; Pervasive/blood/diagnosis/psychology

beta-Endorphin (beta-EP) and cholecystokinin 8 (CCK-8) concentrations in peripheral blood mononuclear cells were measured in 12 drug-free autistic (AU) children, in 10 drug-free children with pervasive developmental disorders (PDD) and in 11 healthy controls. The aim of the study was to see whether or not there was an alteration of beta-EP and CCK-8 concentrations in this peripheral compartment, in which it has been suggested that secretion and regulation of the two peptides mimic those of neurons in the central nervous system. Mean beta-EP values were significantly higher in AU than in PDD and control children, while there were no differences in CCK-8 values of the three groups.

1997

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