Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain

Title

Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain

Creator

Hunt A; Joel S; Dick G; Goldman A

Publisher

Journal Of Pediatrics

Date

1999

Subject

Child; Analgesics; Age Factors; Linear Models; Case-Control Studies; adolescent; Preschool; Non-U.S. Gov't; infant; Comparative Study; Nonparametric; Statistics; Dose-Response Relationship; Drug; Delayed-Action Preparations; Human; Support; Neoplasms/complications; Morphine Derivatives/administration & dosage/blood/pharmacokinetics; Morphine/administration & dosage/blood/pharmacokinetics; Opioid/administration & dosage/blood/pharmacokinetics; Pain/drug therapy/etiology

Description

OBJECTIVES: (1) To determine the pharmacokinetics of morphine, morphine-6-glucuronide (M6G), and morphine-3-glucuronide (M3G) in children with cancer receiving morphine as immediate-release morphine liquid or sustained-release tablets. (2) To determine differences with age within the group and from adults. (3) To explore relationships between plasma concentration and pain measurements. STUDY DESIGN: Blood samples were collected and plasma analyzed by high-performance liquid chromatography with electrochemical and fluorescence detection. Population pharmacokinetic parameters were derived with the program P-PHARM. RESULTS: Forty children with a median age of 11.4 years (range 1.7 to 18.7 years) received a median dose of 1.4 mg/kg/d (range 0.4 to 24.6 mg/kg/d). A median of 4 blood samples per child was collected. Plasma clearance of morphine was 23.1 mL/min per kg body weight. The volume of distribution was 5.2 L/kg. Molar ratios of M3G/morphine, M6G/morphine, and M3G/M6G were 21.1, 4.7, and 4.2, respectively. Children 12 ng/mL in children with cancer pain unrelieved by mild to moderate strength analgesia.
1999

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

47-55

Issue

1

Volume

135

Citation

Hunt A; Joel S; Dick G; Goldman A, “Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain,” Pediatric Palliative Care Library, accessed May 25, 2022, https://pedpalascnetlibrary.omeka.net/items/show/11673.

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