Transdermal fentanyl for pain relief in a paediatric palliative care population

Title

Transdermal fentanyl for pain relief in a paediatric palliative care population

Creator

Hunt A; Goldman A; Devine T; Phillips M

Publisher

Palliative Medicine

Date

2001

Subject

Child; Female; Male; Palliative Care; Pain Measurement; Terminally Ill; Analgesics; Parents; Treatment Outcome; Patient Satisfaction; adolescent; Preschool; Non-U.S. Gov't; Administration; Human; Cutaneous; Support; Pain/drug therapy; Opioid/administration & dosage; Fentanyl/administration & dosage

Description

This multicentre, observational study examined the efficacy of the therapeutic transdermal fentanyl system (TTS-fentanyl) in children requiring opioids for pain in life-threatening disease. Forty-one children receiving oral morphine (median dose 60 mg/day) transferred to transdermal fentanyl (median dose 25 micrograms/h according with the manufacturer's dose conversion guidelines). Twenty-six children completed the 15-day treatment phase, seven died due to disease progression and eight were withdrawn because of adverse events, inadequate analgesia or a change to parenteral opioids. After 15 days, the median fentanyl dose was 75 micrograms/h (range 25-250). No serious adverse events were attributed to fentanyl. There was a trend toward improved side-effects and convenience with fentanyl. Twenty-three of 26 parents (three missing) and 25 of 26 investigators considered transdermal fentanyl to be better than previous treatment. For all records available (at 15 days or on withdrawal if earlier), 75% (27/36) reported that fentanyl treatment was 'good' or 'very good'. The findings suggest that transdermal fentanyl is both effective and acceptable for children and their families.
2001

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation

Hunt A; Goldman A; Devine T; Phillips M, “Transdermal fentanyl for pain relief in a paediatric palliative care population,” Pediatric Palliative Care Library, accessed May 21, 2024, https://pedpalascnetlibrary.omeka.net/items/show/11650.