Oropharyngeal dysphagia and aspiration in patients with ataxia-telangiectasia

Title

Oropharyngeal dysphagia and aspiration in patients with ataxia-telangiectasia

Creator

Lefton-Greif M A; Crawford T O; Winkelstein J A; Loughlin G M; Koerner C B; Zaburak M; Lederman H M

Publisher

Journal of Pediatrics

Date

2000

Subject

children; Pediatrics; feeding difficulties; ataxia telangectasia; trajectory; characteristics; dysphagia aspiration; low weight

Description

Objectives: To determine whether patients with ataxia-telangiectasia exhibit oropharyngeal dysphagia with concomitant aspiration and to examine the relationships among swallowing function, age, and nutritional status. Study design: Seventy patients (mean age, 10.7 years; range,: 1.8 to 30 years) had feeding/swallowing and nutritional evaluations. Fifty-one patients, in whom there were concerns about swallowing safety, were examined with a standardized videofluoroscopic swallow study. Results: Fourteen of the 51 patients (27%) with histories suggestive of dysphagia demonstrated aspiration. Of these, silent aspiration (aspiration without a cough) occurred in 10 (71%) patients. Aspirators were significantly older than non-aspirators (mean age, 16.9 vs 10.8 years; P = .002). Advancing age was the strongest factor associated with aspiration during continuous drinking (P = .01). In patients with ataxia-telangiectasia, weight and weight/height were abnormally low at all ages and most compromised in older patients. Patients who aspirated had significantly lower mean weighs (P < .002) and weight/height z scores (P < .001) than did patients who did not aspirate. Conclusions: Oropharyngeal dysphagia is common and appears to be progressive in patients with ataxia-telangiectasia. Older patients also have a higher incidence of poorer nutritional status. The relationship between dysphagia and nutritional status deserves further investigation.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Lefton-Greif M A; Crawford T O; Winkelstein J A; Loughlin G M; Koerner C B; Zaburak M; Lederman H M, “Oropharyngeal dysphagia and aspiration in patients with ataxia-telangiectasia,” Pediatric Palliative Care Library, accessed October 27, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16722.

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