How children's responses to drugs differ from adults

Title

How children's responses to drugs differ from adults

Creator

Stephenson T

Publisher

British Journal of Clinical Pharmacology

Date

2005

Subject

PedPal Lit; a drug - a truly age-dependent difference in pharmacodynamics. This may be true of both the desired action and adverse events. Examples are given. Programming by drugs is also a phenomenon almost exclusive to early life; Adult Aging/metabolism Bayes Theorem Child Clinical Trials/methods Humans PharmacogeneticsPharmacokinetics Research Design%X Children are not small adults. However; and response to; different 'host' response and different adverse drug reactions can all explain why some drugs behave differently in children. However; different disease variants; different pharmacodynamics; example s are discussed. Different pathophysiology; i.e. permanent effects result from a stimulus applied at a sensitive point in development ('critical window'); often in fetal or neonatal life. Again; stage of development can alter the action of; the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often; we need to explore ways to avoid re-inventing the wheel by determining how data from adult animal and human models can help inform research and practice for children.

Description

2005

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

670-3

Issue

6

Volume

59

Citation

Stephenson T, “How children's responses to drugs differ from adults,” Pediatric Palliative Care Library, accessed December 2, 2021, https://pedpalascnetlibrary.omeka.net/items/show/13491.

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