Methionine enkephalin-like, substance P-like, and beta-endorphin-like immunoreactivity in human parotid saliva

Title

Methionine enkephalin-like, substance P-like, and beta-endorphin-like immunoreactivity in human parotid saliva

Creator

Pikula DL; Harris EF; Desiderio DM; Fridland GH; Lovelace JL

Publisher

Archives Of Oral Biology

Date

1992

Subject

Female; Humans; Male; Adult; Middle Aged; Biomarkers of Pain; beta-Endorphin/analysis; Circadian Rhythm; Enkephalin; Methionine/analysis; Parotid Gland/secretion; Radioimmunoassay; Saliva/chemistry; Salivary Proteins/analysis; Substance P/analysis

Description

These three neuropeptides were measured at daily baseline values by radioimmunoassay. Stimulated parotid saliva was collected from 31 subjects using a modified Carlson-Crittenden device affixed over Stenson's duct. Methionine enkephalin-like immunoreactivity ranged from 6.6 to 11.7 fmol/ml, with a mean of 9.3 fmol/ml. Substance P-like immunoreactivity ranged from 6.1 to 12.6 fmol/ml, with a mean of 9.3 fmol/ml. beta-Endorphin-like immunoreactivity ranged from 1.2 to 3.6 fmol/ml, with a mean of 2.6 fmol/ml. This is believed to be the first documentation of methionine enkephalin- and substance P-like activities in human parotid saliva and the first demonstration of beta-endorphin-like activity in any type of human saliva. Substance P-like activity was significantly higher in morning than evening samples; beta-endorphin-like activity also tended to be higher in the morning samples. Substance P and beta-endorphin-like immunoreactivities covaried in a significant positive manner, suggesting either common control mechanisms or similar responses to physiological variables.
1992

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

705-709

Issue

9

Volume

37

Citation

Pikula DL; Harris EF; Desiderio DM; Fridland GH; Lovelace JL, “Methionine enkephalin-like, substance P-like, and beta-endorphin-like immunoreactivity in human parotid saliva,” Pediatric Palliative Care Library, accessed July 5, 2022, https://pedpalascnetlibrary.omeka.net/items/show/12308.

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