Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children

Title

Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children

Creator

Cazzullo AG; Musetti MC; Musetti L; Bajo S; Sacerdote P; Panerai A

Publisher

European Neuropsychopharmacology

Date

1999

Subject

Child; Humans; Preschool; Biomarkers of Pain; Leukocytes; beta-Endorphin/metabolism; Autistic Disorder/drug therapy/metabolism; Cognition/drug effects; Mononuclear/drug effects/metabolism; Naltrexone/pharmacology/therapeutic use; Narcotic Antagonists/pharmacology/therapeutic use; Stereotyped Behavior/drug effects

Description

We assessed the clinical and biological effects of high-dose, long-term Naltrexone (NTX) treatment in 11 children (3-11 years), who had been diagnosed as autistic. The drug was given following an open design, for 12 weeks. Beta-Endorphin (beta-END) was assayed in peripheral blood mononuclear cells after 1 and 3 months of treatment, and 6 months after the completion of the course. Baseline beta-END levels were higher than in healthy age-matched controls. In seven patients treatment reduced beta-END, whose levels rose in four children. Autistic symptoms were considerably attenuated in all cases, with functional improvements involving several areas. There was a close correlation between the reduction in beta-END levels and the decrease of social withdrawal, and an evident--though weak--correlation between increases in beta-END and decreases in stereotypy and abnormal speech. Both effects persisted after treatment stopped.
1999

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Type

Journal Article

Citation List Month

Backlog

Pages

361-366

Issue

4

Volume

9

Citation

Cazzullo AG; Musetti MC; Musetti L; Bajo S; Sacerdote P; Panerai A, “Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children,” Pediatric Palliative Care Library, accessed September 22, 2021, https://pedpalascnetlibrary.omeka.net/items/show/12190.

Social Bookmarking