Adverse drug reactions to nonsteroidal anti-inflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital

Adverse drug reactions to nonsteroidal anti-inflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital

Titchen T; Cranswick N; Beggs S

British Journal of Clinical Pharmacology

2005

PedPal Lit; Acetaminophen/adverse effects Adolescent Adult Adverse Drug Reaction Reporting Systems Analgesics; at the Royal Children's Hospital (RCH) in Melbourne; Australia prompted review of all of the RCH reactions reported to these agents over 5 years. METHODS: The ADR programme documents both spontaneously reported ADRs and ADRs identified by discharge coding. For this study; celecoxib; for the previous 5-year period; ibuprofen; in patients aged from 4 months to 22 years (median 10 years) were identified. Reactions were predominantly rash (n = 10); including both established and newer agents.; indomethacin; naproxen; Non-Narcotic/adverse effects Anti-Inflammatory Agents; Non-Steroidal/adverse effects Body Weight Child Child; paracetamol and rofecoxib; Pediatric Humans Infant Male Prognosis Respiration Disorders/chemically induced; Preschool Cyclooxygenase Inhibitors/adverse effects Drug Administration Schedule Drug Eruptions/etiology Female Hematemesis/chemically induced Hospitals; reported reactions to aspirin; significant adverse drug reactions (ADRs) to NSAIDs; were retrieved from the hospital ADR database. RESULTS: Nineteen reports of ADRs to NSAIDs and six to paracetamol

2005

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