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- Tags: Adult Aging/metabolism Bayes Theorem Child Clinical Trials/methods Humans PharmacogeneticsPharmacokinetics Research Design%X Children are not small adults. However
How children's responses to drugs differ from adults
Tags: 2005, a drug - a truly age-dependent difference in pharmacodynamics. This may be true of both the desired action and adverse events. Examples are given. Programming by drugs is also a phenomenon almost exclusive to early life, Adult Aging/metabolism Bayes Theorem Child Clinical Trials/methods Humans PharmacogeneticsPharmacokinetics Research Design%X Children are not small adults. However, and response to, Backlog, British Journal of Clinical Pharmacology, different 'host' response and different adverse drug reactions can all explain why some drugs behave differently in children. However, different disease variants, different pharmacodynamics, example s are discussed. Different pathophysiology, i.e. permanent effects result from a stimulus applied at a sensitive point in development ('critical window'), Journal Article, often in fetal or neonatal life. Again, PedPal Lit, stage of development can alter the action of, Stephenson T, the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often, we need to explore ways to avoid re-inventing the wheel by determining how data from adult animal and human models can help inform research and practice for children.