Self-injurious behavior and tuberous sclerosis complex: Frequency and possible associations in a population of 257 patients

Title

Self-injurious behavior and tuberous sclerosis complex: Frequency and possible associations in a population of 257 patients

Creator

Staley B A; Montenegro M A; Major P; Muzykewicz D A; Halpern E F; Kopp C M C; Newberry P; Thiele E A

Publisher

Epilepsy and Behavior

Date

2008

Subject

Epilepsy; Self-injurious behavior; Neurosciences & Neurology; epilepsy; Tuberous sclerosis complex; autism; Psychiatry; gene; aggression; identification; adults; Behavioral problems; Behavioral Sciences; disabilities; Frontal; frontal-lobe seizures; lobe; Tuber location; behavioral problems; tuberous sclerosis; trajectory; characteristics

Description

Self-injurious behavior (SIB) has been observed in people with tuberous sclerosis complex (TSC), although the frequency of SIB in TSC is largely unknown. SIB is associated with intellectual and developmental disabilities, but there is no single cause of SIB. We retrospectively examined the frequency of SIB in a population of 257 patients with TSC and determined possible associations with SIB. We found a 10% frequency of SIB in our TSC population. When compared with patients without psychiatric symptoms, we identified a significantly higher rate of electroencephalographic interictal spikes in the left frontal lobe and a significantly lower number of tubers in the left occipital, parietal, and posterior temporal lobes. We also found that frequency of TSC2 Mutation, history of infantile spasms, history of seizures, mental retardation, and autism are significantly associated with SIB. (C) 2008 Elsevier Inc. All rights reserved.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Staley B A; Montenegro M A; Major P; Muzykewicz D A; Halpern E F; Kopp C M C; Newberry P; Thiele E A, “Self-injurious behavior and tuberous sclerosis complex: Frequency and possible associations in a population of 257 patients,” Pediatric Palliative Care Library, accessed December 8, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16814.

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