Occurrence of the Sandifer complex in the Brachmann-de Lange syndrome
Title
Occurrence of the Sandifer complex in the Brachmann-de Lange syndrome
Creator
Sommer A
Identifier
Publisher
American Journal of Medical Genetics
Date
1993
Subject
Child; Humans; Adult; Adolescent; Infant; Posture; De Lange Syndrome/complications; Esophagitis/complications/prevention & control; Gastroesophageal Reflux/complications; Spasm/complications; Torticollis/complications; NET Files; child; adult; De Lange Syndrome/co [Complications]; Gastroesophageal Reflux/co [Complications]; Torticollis/co [Complications]; Esophagitis/co [Complications]; Esophagitis/pc [Prevention & Control]; Spasm/co [Complications]; feeding difficulties; De Lange syndrome; trajectory; characteristics; gastroesophageal reflux; GERD; Sandifer complex
Description
Gastroesophageal reflux is a common occurrence in infancy. The most severe complications of reflux include torticollis, opisthotonus, and paroxysmal dystonic posture (known as the Sandifer complex). We examined 17 patients now ranging in age from 9 months to 19 years (mean age 11 years) with the Brachmann-de Lange syndrome for evidence of gastroesophageal reflux and found that 13 had not only reflux, but also posturing and behavior consistent with the Sandifer complex. We propose that early recognition of gastroesophageal reflux in these patients may prevent the full picture of the Sandifer complex and allow for medical treatment rather than surgical intervention.
Rights
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URL Address
Citation
Sommer A, “Occurrence of the Sandifer complex in the Brachmann-de Lange syndrome,” Pediatric Palliative Care Library, accessed April 28, 2025, https://pedpalascnetlibrary.omeka.net/items/show/16810.