Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome

Title

Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome

Creator

Nyhan W L; Johnson H G; Kaufman I A; Jones K L

Publisher

Applied Research in Mental Retardation

Date

1980

Subject

behavioral problems; Lesch-Nyhan syndrome; pharmacologic intervention; 5-hydroxy-tryptophan; self-injurious behavior

Description

In a series of patients with the Lesch-Nyhan syndrome a pharmacologic attempt was made to alter the balance of biogenic amines in the central nervous system by increasing the level of serotin. Patients were treated with 5-hydroxytryptophan in combination with a peripheral decarboxylase inhibitor carbidopa and with imipramine. Most patients had a striking alteration in self-mutilative behavior. However, within 1–3 months each became tolerant and this pharmacologic effect could not be produced again even a year later. These observations suggest that the characteristic behavior of the patient with the Lesch-Nyhan syndrome is related to neurotransmitter balance, and that there may be ways to modify it.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Nyhan W L; Johnson H G; Kaufman I A; Jones K L, “Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome,” Pediatric Palliative Care Library, accessed September 20, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16772.

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