DISTURBANCES OF RAPID-EYE-MOVEMENT SLEEP IN 3 BROTHERS WITH PELIZAEUS-MERZBACHER DISEASE

Title

DISTURBANCES OF RAPID-EYE-MOVEMENT SLEEP IN 3 BROTHERS WITH PELIZAEUS-MERZBACHER DISEASE

Creator

Niakan E; Belluomini J; Lemmi H; Summitt R L; Chien L

Publisher

Annals of Neurology

Date

1979

Subject

Neurosciences & Neurology; sleep disturbance/disorders; Pelizaeus-Merzbacher disease; trajectory; characteristics; REM sleep

Description

The electrophysiological features of 3 brothers with the classic form of Pelizaeus-Merzbacher disease (PMD) were studied. Two consecutive overnight polygraphic sleep recordings indicated a gross distortion of rapid-eye-movement (REM) sleep for all patients. A lower than normal percentage of REM sleep in these patients was consistent with their retarded intellectual development, which supports current thinking that REM sleep may be a sensitive index of brain function integrity. Non-rapid-eye-movement (NREM) sleep, in contrast to reported findings in 1 patient with PMD, was uniformly characterized by distinct stages in which the electroencephalograms contained frequent vertex waves and spindles. Tests of peripheral nerve conduction velocity, acoustic brainstem reflexes, and visual and auditory evoked potentials did not indicate any abnormalities, nor did electroencephalograms obtained during wakefulness. One patient did have epileptiform spikes and spike waves recorded during an all-night EEG, an unusual finding in a child with cerebral white matter disease.

Rights

Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Niakan E; Belluomini J; Lemmi H; Summitt R L; Chien L, “DISTURBANCES OF RAPID-EYE-MOVEMENT SLEEP IN 3 BROTHERS WITH PELIZAEUS-MERZBACHER DISEASE,” Pediatric Palliative Care Library, accessed October 19, 2021, https://pedpalascnetlibrary.omeka.net/items/show/16767.

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